caa a22 4500 605534748 CHVBK 20210128100844.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10517-015-2874-0 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2874-0 Antagonists of Metabotropic Glutamate Receptors Prevent the Development of Audiogenic Seizures [Elektronische Daten] [V. Bashkatova, S. Sudakov, H. Prast] Pretreatment with mGluR1 antagonist AIDA (1 mg/kg) nearly completely prevented the onset of tonic-clonic seizures and increased generation of NO in the cerebral cortex of rats with genetically determined audiogenic reaction to acoustic stimulation. Administration of mGluR5 antagonist MPEP (10 mg/kg) before audiogenic exposure was followed by a significant decrease in the degree of seizure and partially prevented increased generation of NO due to acoustic stimulation. These data indicate that mGlu receptors and NO play an important role in the pathogenetic mechanisms of audiogenic seizures. Springer Science+Business Media New York, 2015 metabotropic glutamate receptors nationallicence rats with genetically determined audiogenic reaction nationallicence acoustic stimulation nationallicence seizures nationallicence nitrergic system nationallicence Bashkatova V. P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia aut Sudakov S. P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia aut Prast H. University of Innsbruck, Innsbruck, Austria aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 1-3 0007-4888 159:1<1 2015 159 10517 https://doi.org/10.1007/s10517-015-2874-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2874-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bashkatova V. P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Sudakov S. P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Prast H. University of Innsbruck, Innsbruck, Austria aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 1-3 0007-4888 159:1<1 2015 159 10517