caa a22 4500 605534756 CHVBK 20210128100844.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10517-015-2879-8 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2879-8 Correction of Hormonal and Metabolic Disorders in Male Rats with Developing Experimental Diabetes [Elektronische Daten] [N. Didebulidze, M. Kakabadze, N. Gordadze, I. Latsabidze, M. Kordzaya, I. Sikharulidze] Synthetic radioinert androgen methyltrienolone administered daily for 2 weeks to male rats with severe diabetes led to a sharp increase in blood testosterone and was accompanied by reduction in glucose level due to an increase in tissue sensitivity to insulin. Normalization of plasma testosterone concentration contributed to saturation of active androgen receptors in the myocardium with testosterone; the number of free receptors decreased by 1.8 times. Testosterone that diminishes the catabolic effects of glucocorticoids improved the state of the myocardium, which was confirmed by activation of DNA and RNA synthesis. Springer Science+Business Media New York, 2015 testosterone nationallicence ischemia nationallicence myocardium nationallicence diabetes nationallicence Didebulidze N. I. A. Natishvili Institute of Experimental Morphology of I. Javakhishvili Tbilisi State University, Tbilisi, Georgia aut Kakabadze M. I. A. Natishvili Institute of Experimental Morphology of I. Javakhishvili Tbilisi State University, Tbilisi, Georgia aut Gordadze N. I. A. Natishvili Institute of Experimental Morphology of I. Javakhishvili Tbilisi State University, Tbilisi, Georgia aut Latsabidze I. I. A. Natishvili Institute of Experimental Morphology of I. Javakhishvili Tbilisi State University, Tbilisi, Georgia aut Kordzaya M. I. A. Natishvili Institute of Experimental Morphology of I. Javakhishvili Tbilisi State University, Tbilisi, Georgia aut Sikharulidze I. I. A. Natishvili Institute of Experimental Morphology of I. Javakhishvili Tbilisi State University, Tbilisi, Georgia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 20-23 0007-4888 159:1<20 2015 159 10517 https://doi.org/10.1007/s10517-015-2879-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2879-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Didebulidze N. I. A. Natishvili Institute of Experimental Morphology of I. Javakhishvili Tbilisi State University, Tbilisi, Georgia aut NATIONALLICENCE 700 1- Kakabadze M. I. A. Natishvili Institute of Experimental Morphology of I. Javakhishvili Tbilisi State University, Tbilisi, Georgia aut NATIONALLICENCE 700 1- Gordadze N. I. A. Natishvili Institute of Experimental Morphology of I. Javakhishvili Tbilisi State University, Tbilisi, Georgia aut NATIONALLICENCE 700 1- Latsabidze I. I. A. Natishvili Institute of Experimental Morphology of I. Javakhishvili Tbilisi State University, Tbilisi, Georgia aut NATIONALLICENCE 700 1- Kordzaya M. I. A. Natishvili Institute of Experimental Morphology of I. Javakhishvili Tbilisi State University, Tbilisi, Georgia aut NATIONALLICENCE 700 1- Sikharulidze I. I. A. Natishvili Institute of Experimental Morphology of I. Javakhishvili Tbilisi State University, Tbilisi, Georgia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 20-23 0007-4888 159:1<20 2015 159 10517