Stimulation of Proliferation and Differentiation of Rat Resident Myocardial Cells with Apoptotic Bodies of Cardiomyocytes

Verfasser / Beitragende:
[A. Tyukavin, G. Belostotskaya, T. Golovanova, M. Galagudza, E. Zakharov, N. Burkova, D. Ivkin, A. Karpov]
Ort, Verlag, Jahr:
2015
Enthalten in:
Bulletin of Experimental Biology and Medicine, 159/1(2015-05-01), 138-141
Format:
Artikel (online)
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024 7 0 |a 10.1007/s10517-015-2909-6  |2 doi 
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245 0 0 |a Stimulation of Proliferation and Differentiation of Rat Resident Myocardial Cells with Apoptotic Bodies of Cardiomyocytes  |h [Elektronische Daten]  |c [A. Tyukavin, G. Belostotskaya, T. Golovanova, M. Galagudza, E. Zakharov, N. Burkova, D. Ivkin, A. Karpov] 
520 3 |a Using the cell model of regenerative cardiomyogenesis (formation of contracting cardiomyocyte colonies from resident stem cells), we found that the addition of cardiomyocyte-derived apoptotic bodies to the culture of neonatal myocardial cells stimulated proliferation and differentiation of cardiomyocyte precursors and the frequency of their contraction was 1.5-fold higher than in the control. Systemic administration of cardiomyocyte-derived apoptotic bodies to Wistar rats with chronic postinfarction heart failure during the early period of myocardial remodeling considerably improved the contractile function of the heart. 
540 |a Springer Science+Business Media New York, 2015 
690 7 |a apoptotic bodies  |2 nationallicence 
690 7 |a resident stem cells  |2 nationallicence 
690 7 |a myocardial regeneration  |2 nationallicence 
690 7 |a chronic heart failure  |2 nationallicence 
700 1 |a Tyukavin  |D A.  |u V. A. Almazov Federal Center for Heart, Blood, and Endocrinology, St. Petersburg, Russia  |4 aut 
700 1 |a Belostotskaya  |D G.  |u V. A. Almazov Federal Center for Heart, Blood, and Endocrinology, St. Petersburg, Russia  |4 aut 
700 1 |a Golovanova  |D T.  |u V. A. Almazov Federal Center for Heart, Blood, and Endocrinology, St. Petersburg, Russia  |4 aut 
700 1 |a Galagudza  |D M.  |u V. A. Almazov Federal Center for Heart, Blood, and Endocrinology, St. Petersburg, Russia  |4 aut 
700 1 |a Zakharov  |D E.  |u V. A. Almazov Federal Center for Heart, Blood, and Endocrinology, St. Petersburg, Russia  |4 aut 
700 1 |a Burkova  |D N.  |u V. A. Almazov Federal Center for Heart, Blood, and Endocrinology, St. Petersburg, Russia  |4 aut 
700 1 |a Ivkin  |D D.  |u V. A. Almazov Federal Center for Heart, Blood, and Endocrinology, St. Petersburg, Russia  |4 aut 
700 1 |a Karpov  |D A.  |u V. A. Almazov Federal Center for Heart, Blood, and Endocrinology, St. Petersburg, Russia  |4 aut 
773 0 |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 159/1(2015-05-01), 138-141  |x 0007-4888  |q 159:1<138  |1 2015  |2 159  |o 10517 
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950 |B NATIONALLICENCE  |P 700  |E 1-  |a Tyukavin  |D A.  |u V. A. Almazov Federal Center for Heart, Blood, and Endocrinology, St. Petersburg, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Belostotskaya  |D G.  |u V. A. Almazov Federal Center for Heart, Blood, and Endocrinology, St. Petersburg, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Golovanova  |D T.  |u V. A. Almazov Federal Center for Heart, Blood, and Endocrinology, St. Petersburg, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Galagudza  |D M.  |u V. A. Almazov Federal Center for Heart, Blood, and Endocrinology, St. Petersburg, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Zakharov  |D E.  |u V. A. Almazov Federal Center for Heart, Blood, and Endocrinology, St. Petersburg, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Burkova  |D N.  |u V. A. Almazov Federal Center for Heart, Blood, and Endocrinology, St. Petersburg, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Ivkin  |D D.  |u V. A. Almazov Federal Center for Heart, Blood, and Endocrinology, St. Petersburg, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Karpov  |D A.  |u V. A. Almazov Federal Center for Heart, Blood, and Endocrinology, St. Petersburg, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 773  |E 0-  |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 159/1(2015-05-01), 138-141  |x 0007-4888  |q 159:1<138  |1 2015  |2 159  |o 10517