Changed Serum Cytokine Profile in Mice in Response to Streptococcus A Culture
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2891-z |2 doi |
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| 245 | 0 | 0 | |a Changed Serum Cytokine Profile in Mice in Response to Streptococcus A Culture |h [Elektronische Daten] |c [T. Danilova, A. Adzhieva, G. Danilina, V. Lunin, V. Grabko, A. Minko] |
| 520 | 3 | |a Comparative analysis of serum cytokine profiles of CBA mice was carried out 1, 5, 24, and 48 h after intraperitoneal injection of killed culture of different streptococcus A types. The production of cytokines in response to different streptococcus types varied. The highest level was recorded in response to types 1M and 3T+M, more often detected in invasive streptococcal infection. The highest levels of IL-2 were recorded in response to 1M (47-fold increase in comparison with the control) and 3T+M streptococcus types (more than 10-fold increase). Injections of these types also led to an increase of IFN-γ level (15.6 and 11.3 times, respectively). The level of TNF-α increased less (3.6 times in response to 3T+M and 2.6 times in response to 1M type). The levels of IL-5, IL-10, and IL-12 increased 2-3-fold. Injections of 1T and 5M types led to just a 2-fold increase of cytokine levels. These data indicated induction of the immune response trend by mainly Th1 or mixed Th1/Th2 pattern in response to group A streptococcus antigens. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a cytokines |2 nationallicence | |
| 690 | 7 | |a streptococcus A |2 nationallicence | |
| 690 | 7 | |a immune response |2 nationallicence | |
| 700 | 1 | |a Danilova |D T. |u Laboratory of Microbiology of Latent Infections, Moscow, Russia |4 aut | |
| 700 | 1 | |a Adzhieva |D A. |u Laboratory of Microbiology of Latent Infections, Moscow, Russia |4 aut | |
| 700 | 1 | |a Danilina |D G. |u Laboratory of Microbiology of Latent Infections, Moscow, Russia |4 aut | |
| 700 | 1 | |a Lunin |D V. |u Laboratory of Bioactive Nanostructures, N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | |
| 700 | 1 | |a Grabko |D V. |u Laboratory of Bioactive Nanostructures, N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | |
| 700 | 1 | |a Minko |D A. |u Laboratory of Microbiology of Latent Infections, Moscow, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/1(2015-05-01), 66-69 |x 0007-4888 |q 159:1<66 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2891-z |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2891-z |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Danilova |D T. |u Laboratory of Microbiology of Latent Infections, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Adzhieva |D A. |u Laboratory of Microbiology of Latent Infections, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Danilina |D G. |u Laboratory of Microbiology of Latent Infections, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lunin |D V. |u Laboratory of Bioactive Nanostructures, N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Grabko |D V. |u Laboratory of Bioactive Nanostructures, N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Minko |D A. |u Laboratory of Microbiology of Latent Infections, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/1(2015-05-01), 66-69 |x 0007-4888 |q 159:1<66 |1 2015 |2 159 |o 10517 | ||