caa a22 4500 605534799 CHVBK 20210128100844.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10517-015-2891-z doi (NATIONALLICENCE)springer-10.1007/s10517-015-2891-z Changed Serum Cytokine Profile in Mice in Response to Streptococcus A Culture [Elektronische Daten] [T. Danilova, A. Adzhieva, G. Danilina, V. Lunin, V. Grabko, A. Minko] Comparative analysis of serum cytokine profiles of CBA mice was carried out 1, 5, 24, and 48 h after intraperitoneal injection of killed culture of different streptococcus A types. The production of cytokines in response to different streptococcus types varied. The highest level was recorded in response to types 1M and 3T+M, more often detected in invasive streptococcal infection. The highest levels of IL-2 were recorded in response to 1M (47-fold increase in comparison with the control) and 3T+M streptococcus types (more than 10-fold increase). Injections of these types also led to an increase of IFN-γ level (15.6 and 11.3 times, respectively). The level of TNF-α increased less (3.6 times in response to 3T+M and 2.6 times in response to 1M type). The levels of IL-5, IL-10, and IL-12 increased 2-3-fold. Injections of 1T and 5M types led to just a 2-fold increase of cytokine levels. These data indicated induction of the immune response trend by mainly Th1 or mixed Th1/Th2 pattern in response to group A streptococcus antigens. Springer Science+Business Media New York, 2015 cytokines nationallicence streptococcus A nationallicence immune response nationallicence Danilova T. Laboratory of Microbiology of Latent Infections, Moscow, Russia aut Adzhieva A. Laboratory of Microbiology of Latent Infections, Moscow, Russia aut Danilina G. Laboratory of Microbiology of Latent Infections, Moscow, Russia aut Lunin V. Laboratory of Bioactive Nanostructures, N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia aut Grabko V. Laboratory of Bioactive Nanostructures, N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia aut Minko A. Laboratory of Microbiology of Latent Infections, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 66-69 0007-4888 159:1<66 2015 159 10517 https://doi.org/10.1007/s10517-015-2891-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2891-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Danilova T. Laboratory of Microbiology of Latent Infections, Moscow, Russia aut NATIONALLICENCE 700 1- Adzhieva A. Laboratory of Microbiology of Latent Infections, Moscow, Russia aut NATIONALLICENCE 700 1- Danilina G. Laboratory of Microbiology of Latent Infections, Moscow, Russia aut NATIONALLICENCE 700 1- Lunin V. Laboratory of Bioactive Nanostructures, N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Grabko V. Laboratory of Bioactive Nanostructures, N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Minko A. Laboratory of Microbiology of Latent Infections, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 66-69 0007-4888 159:1<66 2015 159 10517