Different Myocardial Sensitivity in Newborn and Mature Rats to Selective Stimulation of M3 Cholinoreceptors
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2876-y |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-2876-y | ||
| 245 | 0 | 0 | |a Different Myocardial Sensitivity in Newborn and Mature Rats to Selective Stimulation of M3 Cholinoreceptors |h [Elektronische Daten] |c [S. Tapilina, D. Abramochkin] |
| 520 | 3 | |a The effects of selective activation of subtype 3 muscarinic (M3) receptors on electrical activity of isolated preparations of the atrial and ventricular myocardium of the newborn and 4-month-old rats were examined. Application of muscarinic receptor agonist pilocarpine (10-5 M) in preparations with M2 cholinoreceptors blocked by selective antagonist methoctramine (10-7 M) decreased the duration of action potentials in the atrial and ventricular myocardium. Selective blocker of M3 cholinoreceptors 4-DAMP (10-8 M) prevented this effect. While stimulation of ventricular M3 cholinoreceptors with pilocarpine was significantly stronger in newborn pups than in mature rats, similar stimulation of atrial receptors revealed no significant difference in both groups. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a cardiac muscarinic receptors |2 nationallicence | |
| 690 | 7 | |a acetylcholine |2 nationallicence | |
| 690 | 7 | |a atrium |2 nationallicence | |
| 690 | 7 | |a ventricle |2 nationallicence | |
| 690 | 7 | |a action potential |2 nationallicence | |
| 700 | 1 | |a Tapilina |D S. |u Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia |4 aut | |
| 700 | 1 | |a Abramochkin |D D. |u Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/1(2015-05-01), 8-10 |x 0007-4888 |q 159:1<8 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2876-y |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2876-y |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tapilina |D S. |u Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Abramochkin |D D. |u Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/1(2015-05-01), 8-10 |x 0007-4888 |q 159:1<8 |1 2015 |2 159 |o 10517 | ||