caa a22 4500 605534829 CHVBK 20210128100844.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10517-015-2876-y doi (NATIONALLICENCE)springer-10.1007/s10517-015-2876-y Different Myocardial Sensitivity in Newborn and Mature Rats to Selective Stimulation of M3 Cholinoreceptors [Elektronische Daten] [S. Tapilina, D. Abramochkin] The effects of selective activation of subtype 3 muscarinic (M3) receptors on electrical activity of isolated preparations of the atrial and ventricular myocardium of the newborn and 4-month-old rats were examined. Application of muscarinic receptor agonist pilocarpine (10-5 M) in preparations with M2 cholinoreceptors blocked by selective antagonist methoctramine (10-7 M) decreased the duration of action potentials in the atrial and ventricular myocardium. Selective blocker of M3 cholinoreceptors 4-DAMP (10-8 M) prevented this effect. While stimulation of ventricular M3 cholinoreceptors with pilocarpine was significantly stronger in newborn pups than in mature rats, similar stimulation of atrial receptors revealed no significant difference in both groups. Springer Science+Business Media New York, 2015 cardiac muscarinic receptors nationallicence acetylcholine nationallicence atrium nationallicence ventricle nationallicence action potential nationallicence Tapilina S. Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia aut Abramochkin D. Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 8-10 0007-4888 159:1<8 2015 159 10517 https://doi.org/10.1007/s10517-015-2876-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2876-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tapilina S. Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia aut NATIONALLICENCE 700 1- Abramochkin D. Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 8-10 0007-4888 159:1<8 2015 159 10517