caa a22 4500 605534837 CHVBK 20210128100844.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10517-015-2886-9 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2886-9 Cytoprotective Effect of Afobazole and Its Main Metabolite M-11 [Elektronische Daten] [I. Kadnikov, M. Voronin, S. Seredenin] Cell damage depending on activity of quinone reductase 2 (MT3 receptor) was simulated in experiments on bone marrow cell suspension and assessed by menadione-induced DNA breaks measured by comet assay. We analyzed the protective effect of afobazole interacting with MT1, MT3, σ1 receptors, and monoamine oxidase A and its main metabolite M11 that specifi cally binds to MT3 receptors. Both compounds reduced the level of menadione-induced DNA damage (afobazole was effective in lower concentrations in comparison with M-11). Conclusion was made on the contribution of MT3 receptors to the protective effect of afobazole, but the observed concentration differences indicate possible contribution of other targets of anxiolytic drug to the protective mechanisms. Springer Science+Business Media New York, 2015 afobazole nationallicence MT3 receptor nationallicence quinone reductase 2 nationallicence cytoprotection nationallicence Kadnikov I. V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut Voronin M. V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut Seredenin S. V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 44-47 0007-4888 159:1<44 2015 159 10517 https://doi.org/10.1007/s10517-015-2886-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2886-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kadnikov I. V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Voronin M. V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Seredenin S. V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 44-47 0007-4888 159:1<44 2015 159 10517