Cuprizone Model as a Tool for Preclinical Studies of the Efficacy of Multiple Sclerosis Diagnosis and Therapy
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 605534888 | ||
| 003 | CHVBK | ||
| 005 | 20210128100844.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 210128e20150501xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s10517-015-2903-z |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-2903-z | ||
| 245 | 0 | 0 | |a Cuprizone Model as a Tool for Preclinical Studies of the Efficacy of Multiple Sclerosis Diagnosis and Therapy |h [Elektronische Daten] |c [T. Abakumova, A. Kuz'kina, M. Zharova, D. Pozdeeva, I. Gubskii, I. Shepeleva, O. Antonova, N. Nukolova, Z. Kekelidze, V. Chekhonin] |
| 520 | 3 | |a To study demyelination and remyelination processes and their response to different drugs, a protocol for modeling multiple sclerosis using the copper chelator cuprizone was developed. Magnetic resonance imaging confirmed the presence of demyelination lesions on week 4 of 0.6% cuprizone-containing diet. Immunohistochemical staining with polyclonal antibodies to glial fibrillary acidic protein (pAb GFAP) confirmed the increase in the number of reactive astrocytes on week 4 of diet and during remyelination (week 2 after diet). Analysis of neurophysiological functions in mice with cuprizone-induced demyelination revealed motor and behavioral deficits. This model can be used as a tool for preclinical studies of the efficiency of multiple sclerosis diagnostic and therapy. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a multiple sclerosis |2 nationallicence | |
| 690 | 7 | |a cuprizone |2 nationallicence | |
| 690 | 7 | |a demyelination |2 nationallicence | |
| 690 | 7 | |a remyelination |2 nationallicence | |
| 700 | 1 | |a Abakumova |D T. |u V. P. Serbsky State Research Center for Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | |
| 700 | 1 | |a Kuz'kina |D A. |u V. P. Serbsky State Research Center for Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | |
| 700 | 1 | |a Zharova |D M. |u V. P. Serbsky State Research Center for Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | |
| 700 | 1 | |a Pozdeeva |D D. |u V. P. Serbsky State Research Center for Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | |
| 700 | 1 | |a Gubskii |D I. |u V. P. Serbsky State Research Center for Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | |
| 700 | 1 | |a Shepeleva |D I. |u V. P. Serbsky State Research Center for Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | |
| 700 | 1 | |a Antonova |D O. |u V. P. Serbsky State Research Center for Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | |
| 700 | 1 | |a Nukolova |D N. |u V. P. Serbsky State Research Center for Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | |
| 700 | 1 | |a Kekelidze |D Z. |u V. P. Serbsky State Research Center for Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | |
| 700 | 1 | |a Chekhonin |D V. |u V. P. Serbsky State Research Center for Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/1(2015-05-01), 111-115 |x 0007-4888 |q 159:1<111 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2903-z |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2903-z |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Abakumova |D T. |u V. P. Serbsky State Research Center for Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kuz'kina |D A. |u V. P. Serbsky State Research Center for Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zharova |D M. |u V. P. Serbsky State Research Center for Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Pozdeeva |D D. |u V. P. Serbsky State Research Center for Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gubskii |D I. |u V. P. Serbsky State Research Center for Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shepeleva |D I. |u V. P. Serbsky State Research Center for Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Antonova |D O. |u V. P. Serbsky State Research Center for Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nukolova |D N. |u V. P. Serbsky State Research Center for Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kekelidze |D Z. |u V. P. Serbsky State Research Center for Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chekhonin |D V. |u V. P. Serbsky State Research Center for Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/1(2015-05-01), 111-115 |x 0007-4888 |q 159:1<111 |1 2015 |2 159 |o 10517 | ||