Dipeptides Increase Functional Activity of Human Skin Fibroblasts
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2914-9 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-2914-9 | ||
| 245 | 0 | 0 | |a Dipeptides Increase Functional Activity of Human Skin Fibroblasts |h [Elektronische Daten] |c [V. Malinin, A. Durnova, V. Polyakova, I. Kvetnoi] |
| 520 | 3 | |a We analyzed the effect of dipeptide Glu-Trp and isovaleroyl-Glu-Trp in concentrations of 0.2, 2 and 20 μg/ml and Actovegin preparation on functional activity of human skin fibroblasts. Dipeptides, especially Glu-Trp, produce a stimulating effect on human skin fibroblasts and their effect is equivalent to that of Actovegin. Dipeptides stimulate cell renewal processes by activating synthesis of Ki-67 and reducing expression of caspase-9 and enhance antioxidant function of the cells by stimulating the expression of Hsp-90 and inducible NO-synthase. These findings suggest that dipeptides are promising candidates for preparations stimulating reparative processes. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a skin |2 nationallicence | |
| 690 | 7 | |a dipeptides |2 nationallicence | |
| 690 | 7 | |a signal molecules |2 nationallicence | |
| 690 | 7 | |a reparation |2 nationallicence | |
| 700 | 1 | |a Malinin |D V. |u Cytomed Medico-Biological Research-and-Production Complex, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Durnova |D A. |u D. O. Ott Research Institute of Obstetrics and Gynecology, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Polyakova |D V. |u D. O. Ott Research Institute of Obstetrics and Gynecology, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Kvetnoi |D I. |u D. O. Ott Research Institute of Obstetrics and Gynecology, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/1(2015-05-01), 164-167 |x 0007-4888 |q 159:1<164 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2914-9 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2914-9 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Malinin |D V. |u Cytomed Medico-Biological Research-and-Production Complex, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Durnova |D A. |u D. O. Ott Research Institute of Obstetrics and Gynecology, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Polyakova |D V. |u D. O. Ott Research Institute of Obstetrics and Gynecology, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kvetnoi |D I. |u D. O. Ott Research Institute of Obstetrics and Gynecology, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/1(2015-05-01), 164-167 |x 0007-4888 |q 159:1<164 |1 2015 |2 159 |o 10517 | ||