caa a22 4500 605534896 CHVBK 20210128100844.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10517-015-2914-9 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2914-9 Dipeptides Increase Functional Activity of Human Skin Fibroblasts [Elektronische Daten] [V. Malinin, A. Durnova, V. Polyakova, I. Kvetnoi] We analyzed the effect of dipeptide Glu-Trp and isovaleroyl-Glu-Trp in concentrations of 0.2, 2 and 20 μg/ml and Actovegin preparation on functional activity of human skin fibroblasts. Dipeptides, especially Glu-Trp, produce a stimulating effect on human skin fibroblasts and their effect is equivalent to that of Actovegin. Dipeptides stimulate cell renewal processes by activating synthesis of Ki-67 and reducing expression of caspase-9 and enhance antioxidant function of the cells by stimulating the expression of Hsp-90 and inducible NO-synthase. These findings suggest that dipeptides are promising candidates for preparations stimulating reparative processes. Springer Science+Business Media New York, 2015 skin nationallicence dipeptides nationallicence signal molecules nationallicence reparation nationallicence Malinin V. Cytomed Medico-Biological Research-and-Production Complex, St. Petersburg, Russia aut Durnova A. D. O. Ott Research Institute of Obstetrics and Gynecology, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia aut Polyakova V. D. O. Ott Research Institute of Obstetrics and Gynecology, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia aut Kvetnoi I. D. O. Ott Research Institute of Obstetrics and Gynecology, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 164-167 0007-4888 159:1<164 2015 159 10517 https://doi.org/10.1007/s10517-015-2914-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2914-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Malinin V. Cytomed Medico-Biological Research-and-Production Complex, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Durnova A. D. O. Ott Research Institute of Obstetrics and Gynecology, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Polyakova V. D. O. Ott Research Institute of Obstetrics and Gynecology, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Kvetnoi I. D. O. Ott Research Institute of Obstetrics and Gynecology, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 164-167 0007-4888 159:1<164 2015 159 10517