caa a22 4500 60553490X CHVBK 20210128100845.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10517-015-2900-2 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2900-2 Experimental Modeling of Proliferative Vitreoretinopathy. An Experimental Morphological Study [Elektronische Daten] [I. Khoroshilova-Maslova, N. Leparskaya, M. Nabieva, L. Andreeva] A model of proliferative vitreoretinopathy induced by simultaneous intravitreal injection of recombinant IL-1β and platelet concentrate is created and its main morphological manifestations are studied on Chinchilla rabbits. The model reflects pathogenesis of proliferative vitreoretinopathy: epiretinal membrane with the formation of retinal plication, traction detachment of the retina; moderate inflammatory reaction in the uveal tract, in the optic nerve infundibulum, in the vitreous body; intact structural elements of the retina, dissociation of the retinal pigmented epithelium cells with their subsequent migration. The model is adequate to the clinical picture of proliferative vitreoretinopathy in humans, which recommends it for experimental studies of the efficiency of drug therapy and prevention of this disease. Springer Science+Business Media New York, 2015 proliferative vitreoretinopathy nationallicence interleukine-1β nationallicence platelet concentrate nationallicence epiretinal membrane nationallicence Khoroshilova-Maslova I. Helmholtz Moscow Research Institute of Ocular Diseases, Ministry of Health of the Russian Federation, Moscow, Russia aut Leparskaya N. Helmholtz Moscow Research Institute of Ocular Diseases, Ministry of Health of the Russian Federation, Moscow, Russia aut Nabieva M. Helmholtz Moscow Research Institute of Ocular Diseases, Ministry of Health of the Russian Federation, Moscow, Russia aut Andreeva L. Helmholtz Moscow Research Institute of Ocular Diseases, Ministry of Health of the Russian Federation, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 100-102 0007-4888 159:1<100 2015 159 10517 https://doi.org/10.1007/s10517-015-2900-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2900-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Khoroshilova-Maslova I. Helmholtz Moscow Research Institute of Ocular Diseases, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Leparskaya N. Helmholtz Moscow Research Institute of Ocular Diseases, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Nabieva M. Helmholtz Moscow Research Institute of Ocular Diseases, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Andreeva L. Helmholtz Moscow Research Institute of Ocular Diseases, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 100-102 0007-4888 159:1<100 2015 159 10517