caa a22 4500 605534918 CHVBK 20210128100845.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10517-015-2888-7 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2888-7 Intraperitoneal Administration of Muramyl Dipeptide β-Heptylglycoside to Pregnant and Non-Pregnant Female Mice Modulates Production of Th1/Th2/Th17/Tr1 Cytokines by Splenocytes Ex Vivo [Elektronische Daten] [O. Kalyuzhin, K. Artem'eva, M. Boltovskaya, K. Bunyatyan, E. Inviyayeva, L. Vinnitskii, A. Karaulov] Muramyl dipeptide β-heptylglycoside (C7MDP) was administered to non-pregnant CBA female mice and pregnant mice after non-abortion-prone mating (CBA×BALB/c) and mating associated with a high rate of spontaneous abortion (CBA×DBA/2). In non-pregnant females, C7MDP increased the production of IL-2, IL-4, IL-5, IL-6, IL-17, IFNγ, TNFα, and GM-CSF at constant production of IL-1α and IL-10. C7MDP increased the production of IL-10 and IL-17 and suppressed the production of IFNγ on day 8 of gestation in non-abortion-prone mouse couples and stimulated the synthesis of IL-4 and IFNγ, reduced IL-5 production, and slightly increased IL-1α secretion after abortion-prone mating. On day 14 of gestation, C7MDP elevated the yield of IL-2, IL-4, IFNγ, TNFα, and GM-CSF in CBA×BALB/c and CBA×DBA/2 couples and IL-17 in the fi rst variant of mating. Springer Science+Business Media New York, 2015 muramyl dipeptide β-heptylglycoside nationallicence mouse model of miscarriage nationallicence Th1/Th2/ Th17/Tr1 cytokines nationallicence Kalyuzhin O. Department of Clinical Immunology and Allergology, I. M. Sechenov First Moscow State Medical University, Ministry of Health, Russian Federation, Moscow, Russia aut Artem'eva K. Laboratory of Cell Biotechnology and Immunopathology, Research Institute of Human Morphology, Moscow, Russia aut Boltovskaya M. Laboratory of Cell Biotechnology and Immunopathology, Research Institute of Human Morphology, Moscow, Russia aut Bunyatyan K. Laboratory of Immunology and Regulatory Mechanisms in Surgery, B. V. Petrovskii Russian Research Center of Surgery, Moscow, Russia aut Inviyayeva E. Laboratory of Immunology and Regulatory Mechanisms in Surgery, B. V. Petrovskii Russian Research Center of Surgery, Moscow, Russia aut Vinnitskii L. Laboratory of Immunology and Regulatory Mechanisms in Surgery, B. V. Petrovskii Russian Research Center of Surgery, Moscow, Russia aut Karaulov A. Department of Clinical Immunology and Allergology, I. M. Sechenov First Moscow State Medical University, Ministry of Health, Russian Federation, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 53-57 0007-4888 159:1<53 2015 159 10517 https://doi.org/10.1007/s10517-015-2888-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2888-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kalyuzhin O. Department of Clinical Immunology and Allergology, I. M. Sechenov First Moscow State Medical University, Ministry of Health, Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Artem'eva K. Laboratory of Cell Biotechnology and Immunopathology, Research Institute of Human Morphology, Moscow, Russia aut NATIONALLICENCE 700 1- Boltovskaya M. Laboratory of Cell Biotechnology and Immunopathology, Research Institute of Human Morphology, Moscow, Russia aut NATIONALLICENCE 700 1- Bunyatyan K. Laboratory of Immunology and Regulatory Mechanisms in Surgery, B. V. Petrovskii Russian Research Center of Surgery, Moscow, Russia aut NATIONALLICENCE 700 1- Inviyayeva E. Laboratory of Immunology and Regulatory Mechanisms in Surgery, B. V. Petrovskii Russian Research Center of Surgery, Moscow, Russia aut NATIONALLICENCE 700 1- Vinnitskii L. Laboratory of Immunology and Regulatory Mechanisms in Surgery, B. V. Petrovskii Russian Research Center of Surgery, Moscow, Russia aut NATIONALLICENCE 700 1- Karaulov A. Department of Clinical Immunology and Allergology, I. M. Sechenov First Moscow State Medical University, Ministry of Health, Russian Federation, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 53-57 0007-4888 159:1<53 2015 159 10517