Antioxidant Defense System after Single and Chronic Administration of Obestatin and Its Fragment (1-4) to Normal and Overweight Male Rats

Verfasser / Beitragende:
[E. Khirazova, A. Bayzhumanov, E. Motorykina, A. Devyatov, M. Maslova, A. Graf, N. Sokolova, M. Golubeva, A. Kamenskii]
Ort, Verlag, Jahr:
2015
Enthalten in:
Bulletin of Experimental Biology and Medicine, 159/1(2015-05-01), 38-40
Format:
Artikel (online)
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024 7 0 |a 10.1007/s10517-015-2884-y  |2 doi 
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245 0 0 |a Antioxidant Defense System after Single and Chronic Administration of Obestatin and Its Fragment (1-4) to Normal and Overweight Male Rats  |h [Elektronische Daten]  |c [E. Khirazova, A. Bayzhumanov, E. Motorykina, A. Devyatov, M. Maslova, A. Graf, N. Sokolova, M. Golubeva, A. Kamenskii] 
520 3 |a We studied the effects of anorectic peptide obestatin and its fragment (1-4) on the antioxidant defense system in animals with normal and experimentally induced increased body weight. In rats with normal body weight, no changes in activity of the antioxidant defense system 1 week after single administration of the substances. After chronic administration of obestatin and fragment (1-4) for 1 week, total antioxidant capacity of the plasma decreased; obestatin also lowered the content of TBA-reactive products. In the overweight rats, SOD-like activity in the plasma increased 1 week after chronic administration of obestatin. Hence, obestatin and its fragment (1-4) induced changes in the antioxidant defense system only after chronic administration. 
540 |a Springer Science+Business Media New York, 2015 
690 7 |a obestatin  |2 nationallicence 
690 7 |a antioxidant defense system  |2 nationallicence 
690 7 |a overweight  |2 nationallicence 
700 1 |a Khirazova  |D E.  |u Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia  |4 aut 
700 1 |a Bayzhumanov  |D A.  |u Department of Biophysics, Biological Faculty, M. V. Lomonosov State Moscow University, Moscow, Russia  |4 aut 
700 1 |a Motorykina  |D E.  |u Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia  |4 aut 
700 1 |a Devyatov  |D A.  |u Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia  |4 aut 
700 1 |a Maslova  |D M.  |u Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia  |4 aut 
700 1 |a Graf  |D A.  |u Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia  |4 aut 
700 1 |a Sokolova  |D N.  |u Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia  |4 aut 
700 1 |a Golubeva  |D M.  |u Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia  |4 aut 
700 1 |a Kamenskii  |D A.  |u Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia  |4 aut 
773 0 |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 159/1(2015-05-01), 38-40  |x 0007-4888  |q 159:1<38  |1 2015  |2 159  |o 10517 
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950 |B NATIONALLICENCE  |P 856  |E 40  |u https://doi.org/10.1007/s10517-015-2884-y  |q text/html  |z Onlinezugriff via DOI 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Khirazova  |D E.  |u Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Bayzhumanov  |D A.  |u Department of Biophysics, Biological Faculty, M. V. Lomonosov State Moscow University, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Motorykina  |D E.  |u Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Devyatov  |D A.  |u Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Maslova  |D M.  |u Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Graf  |D A.  |u Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Sokolova  |D N.  |u Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Golubeva  |D M.  |u Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Kamenskii  |D A.  |u Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 773  |E 0-  |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 159/1(2015-05-01), 38-40  |x 0007-4888  |q 159:1<38  |1 2015  |2 159  |o 10517