caa a22 4500 605534926 CHVBK 20210128100845.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10517-015-2884-y doi (NATIONALLICENCE)springer-10.1007/s10517-015-2884-y Antioxidant Defense System after Single and Chronic Administration of Obestatin and Its Fragment (1-4) to Normal and Overweight Male Rats [Elektronische Daten] [E. Khirazova, A. Bayzhumanov, E. Motorykina, A. Devyatov, M. Maslova, A. Graf, N. Sokolova, M. Golubeva, A. Kamenskii] We studied the effects of anorectic peptide obestatin and its fragment (1-4) on the antioxidant defense system in animals with normal and experimentally induced increased body weight. In rats with normal body weight, no changes in activity of the antioxidant defense system 1 week after single administration of the substances. After chronic administration of obestatin and fragment (1-4) for 1 week, total antioxidant capacity of the plasma decreased; obestatin also lowered the content of TBA-reactive products. In the overweight rats, SOD-like activity in the plasma increased 1 week after chronic administration of obestatin. Hence, obestatin and its fragment (1-4) induced changes in the antioxidant defense system only after chronic administration. Springer Science+Business Media New York, 2015 obestatin nationallicence antioxidant defense system nationallicence overweight nationallicence Khirazova E. Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia aut Bayzhumanov A. Department of Biophysics, Biological Faculty, M. V. Lomonosov State Moscow University, Moscow, Russia aut Motorykina E. Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia aut Devyatov A. Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia aut Maslova M. Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia aut Graf A. Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia aut Sokolova N. Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia aut Golubeva M. Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia aut Kamenskii A. Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 38-40 0007-4888 159:1<38 2015 159 10517 https://doi.org/10.1007/s10517-015-2884-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2884-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Khirazova E. Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia aut NATIONALLICENCE 700 1- Bayzhumanov A. Department of Biophysics, Biological Faculty, M. V. Lomonosov State Moscow University, Moscow, Russia aut NATIONALLICENCE 700 1- Motorykina E. Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia aut NATIONALLICENCE 700 1- Devyatov A. Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia aut NATIONALLICENCE 700 1- Maslova M. Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia aut NATIONALLICENCE 700 1- Graf A. Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia aut NATIONALLICENCE 700 1- Sokolova N. Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia aut NATIONALLICENCE 700 1- Golubeva M. Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia aut NATIONALLICENCE 700 1- Kamenskii A. Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 38-40 0007-4888 159:1<38 2015 159 10517