Association of Polymorphisms in Innate Immunity Genes TLR9 and DEFB1 with Human Longevity
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2894-9 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-2894-9 | ||
| 245 | 0 | 0 | |a Association of Polymorphisms in Innate Immunity Genes TLR9 and DEFB1 with Human Longevity |h [Elektronische Daten] |c [L. Gankovskaya, O. Svitich, O. Artem'eva, A. Miroshnichenkova, K. Rusanova] |
| 520 | 3 | |a The distribution of polymorphic variants of innate immunity genes TLR9 (+2848G>A) and DEFB1(−20G>A; −44C>G; −52G>A) was evaluated in long-living individuals. No significant differences were found in the distribution of genotypes and alleles of the TLR9 gene. The following features were revealed: increase in the frequency of AA and GG genotypes and decrease in the frequency of the AG genotype of the DEFB1(−20G>A) gene; increase in the frequency of the CC genotype and C allele and decrease in the frequency of CG and GG genotypes and G allele of the DEFB1(44C>G) gene; and increase in the frequency of AA and AG genotypes and A allele and decrease in the frequency of the GG genotypes and G allele of the DEFB1(−52G>A) gene. Genotypes and alleles of the DEFB1 gene found in long-living individuals can be considered as the factors that increase the probability of longevity and favorable course of age-related diseases. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a aging |2 nationallicence | |
| 690 | 7 | |a gene polymorphism |2 nationallicence | |
| 690 | 7 | |a innate immunity |2 nationallicence | |
| 690 | 7 | |a Toll-like receptor |2 nationallicence | |
| 690 | 7 | |a β-defensin-1 |2 nationallicence | |
| 700 | 1 | |a Gankovskaya |D L. |u N. I. Pirogov Russian National Research Medical University, Moscow, Russia |4 aut | |
| 700 | 1 | |a Svitich |D O. |u N. I. Pirogov Russian National Research Medical University, Moscow, Russia |4 aut | |
| 700 | 1 | |a Artem'eva |D O. |u N. I. Pirogov Russian National Research Medical University, Moscow, Russia |4 aut | |
| 700 | 1 | |a Miroshnichenkova |D A. |u N. I. Pirogov Russian National Research Medical University, Moscow, Russia |4 aut | |
| 700 | 1 | |a Rusanova |D K. |u N. I. Pirogov Russian National Research Medical University, Moscow, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/1(2015-05-01), 77-80 |x 0007-4888 |q 159:1<77 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2894-9 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2894-9 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gankovskaya |D L. |u N. I. Pirogov Russian National Research Medical University, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Svitich |D O. |u N. I. Pirogov Russian National Research Medical University, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Artem'eva |D O. |u N. I. Pirogov Russian National Research Medical University, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Miroshnichenkova |D A. |u N. I. Pirogov Russian National Research Medical University, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rusanova |D K. |u N. I. Pirogov Russian National Research Medical University, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/1(2015-05-01), 77-80 |x 0007-4888 |q 159:1<77 |1 2015 |2 159 |o 10517 | ||