caa a22 4500 605534942 CHVBK 20210128100845.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10517-015-2894-9 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2894-9 Association of Polymorphisms in Innate Immunity Genes TLR9 and DEFB1 with Human Longevity [Elektronische Daten] [L. Gankovskaya, O. Svitich, O. Artem'eva, A. Miroshnichenkova, K. Rusanova] The distribution of polymorphic variants of innate immunity genes TLR9 (+2848G>A) and DEFB1(−20G>A; −44C>G; −52G>A) was evaluated in long-living individuals. No significant differences were found in the distribution of genotypes and alleles of the TLR9 gene. The following features were revealed: increase in the frequency of AA and GG genotypes and decrease in the frequency of the AG genotype of the DEFB1(−20G>A) gene; increase in the frequency of the CC genotype and C allele and decrease in the frequency of CG and GG genotypes and G allele of the DEFB1(44C>G) gene; and increase in the frequency of AA and AG genotypes and A allele and decrease in the frequency of the GG genotypes and G allele of the DEFB1(−52G>A) gene. Genotypes and alleles of the DEFB1 gene found in long-living individuals can be considered as the factors that increase the probability of longevity and favorable course of age-related diseases. Springer Science+Business Media New York, 2015 aging nationallicence gene polymorphism nationallicence innate immunity nationallicence Toll-like receptor nationallicence β-defensin-1 nationallicence Gankovskaya L. N. I. Pirogov Russian National Research Medical University, Moscow, Russia aut Svitich O. N. I. Pirogov Russian National Research Medical University, Moscow, Russia aut Artem'eva O. N. I. Pirogov Russian National Research Medical University, Moscow, Russia aut Miroshnichenkova A. N. I. Pirogov Russian National Research Medical University, Moscow, Russia aut Rusanova K. N. I. Pirogov Russian National Research Medical University, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 77-80 0007-4888 159:1<77 2015 159 10517 https://doi.org/10.1007/s10517-015-2894-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2894-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gankovskaya L. N. I. Pirogov Russian National Research Medical University, Moscow, Russia aut NATIONALLICENCE 700 1- Svitich O. N. I. Pirogov Russian National Research Medical University, Moscow, Russia aut NATIONALLICENCE 700 1- Artem'eva O. N. I. Pirogov Russian National Research Medical University, Moscow, Russia aut NATIONALLICENCE 700 1- Miroshnichenkova A. N. I. Pirogov Russian National Research Medical University, Moscow, Russia aut NATIONALLICENCE 700 1- Rusanova K. N. I. Pirogov Russian National Research Medical University, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 77-80 0007-4888 159:1<77 2015 159 10517