Involvement of PI3K, MAPK ERK1/2 and p38 in Functional Stimulation of Mesenchymal Progenitor Cells by Alkaloid Songorine

Verfasser / Beitragende:
[G. Zyuz'kov, V. Zhdanov, L. Miroshnichenko, E. Udut, A. Chaikovskii, E. Simanina, M. Danilets, M. Minakova, V. Udut, T. Tolstikova, E. Shults, L. Stavrova, Ya. Burmina, A. Dygai]
Ort, Verlag, Jahr:
2015
Enthalten in:
Bulletin of Experimental Biology and Medicine, 159/1(2015-05-01), 58-61
Format:
Artikel (online)
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024 7 0 |a 10.1007/s10517-015-2889-6  |2 doi 
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245 0 0 |a Involvement of PI3K, MAPK ERK1/2 and p38 in Functional Stimulation of Mesenchymal Progenitor Cells by Alkaloid Songorine  |h [Elektronische Daten]  |c [G. Zyuz'kov, V. Zhdanov, L. Miroshnichenko, E. Udut, A. Chaikovskii, E. Simanina, M. Danilets, M. Minakova, V. Udut, T. Tolstikova, E. Shults, L. Stavrova, Ya. Burmina, A. Dygai] 
520 3 |a We studied the role of intracellular signaling molecules PI3K, МАРK ERK1/2, and р38 in stimulation of realization of the growth potential of mesenchymal progenitor cells by alkaloid songorine in vitro. Inhibitors of PI3K, ERK1/2 and р38 canceled the increase in proliferative activity of progenitor cells, the blockers of ERK1/2 and р38 reduced the intensity of progenitor cell differentiation. 
540 |a Springer Science+Business Media New York, 2015 
690 7 |a PI3K  |2 nationallicence 
690 7 |a МАРK  |2 nationallicence 
690 7 |a alkaloids  |2 nationallicence 
690 7 |a progenitor cells  |2 nationallicence 
690 7 |a regenerative medicine  |2 nationallicence 
700 1 |a Zyuz'kov  |D G.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Zhdanov  |D V.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Miroshnichenko  |D L.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Udut  |D E.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Chaikovskii  |D A.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Simanina  |D E.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Danilets  |D M.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Minakova  |D M.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Udut  |D V.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Tolstikova  |D T.  |u N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia  |4 aut 
700 1 |a Shults  |D E.  |u N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia  |4 aut 
700 1 |a Stavrova  |D L.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Burmina  |D Ya  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Dygai  |D A.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
773 0 |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 159/1(2015-05-01), 58-61  |x 0007-4888  |q 159:1<58  |1 2015  |2 159  |o 10517 
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950 |B NATIONALLICENCE  |P 700  |E 1-  |a Zyuz'kov  |D G.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Zhdanov  |D V.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Miroshnichenko  |D L.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Udut  |D E.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Chaikovskii  |D A.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Simanina  |D E.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Danilets  |D M.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Minakova  |D M.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Udut  |D V.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Tolstikova  |D T.  |u N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Shults  |D E.  |u N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Stavrova  |D L.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Burmina  |D Ya  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Dygai  |D A.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 773  |E 0-  |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 159/1(2015-05-01), 58-61  |x 0007-4888  |q 159:1<58  |1 2015  |2 159  |o 10517