caa a22 4500 605534969 CHVBK 20210128100845.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10517-015-2895-8 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2895-8 Simulation of Chemoperfusion Treatment for Abdominal Carcinomatosis [Elektronische Daten] [V. Bespalov, O. Belyaeva, G. Kireeva, K. Senchik, A. Stukov, A. Belyaev] Experimental perfusion system and technology for normothermic and hyperthermic intraperitoneal chemoperfusion are developed for the treatment of abdominal carcinomatosis in rats with transplanted ovarian cancer. MTD of cisplatin in normothermic intraperitoneal chemoperfusion and hyperthermic perfusion are 40 and 20 mg/kg, i.e. by 10- and 5-fold higher than the dose of this cytostatic for routine intraperitoneal injection. Normothermic intraperitoneal chemoperfusion with cisplatin increases median survival time by 200% (p=0.039) in comparison with intraperitoneal injection. Springer Science+Business Media New York, 2015 intraperitoneal chemoperfusion nationallicence ovarian cancer nationallicence cisplatin nationallicence Bespalov V. Laboratory of Cancer Chemotherapeutic Prevention and Oncopharmacology, N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut Belyaeva O. Laboratory of Cancer Chemotherapeutic Prevention and Oncopharmacology, N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut Kireeva G. Laboratory of Cancer Chemotherapeutic Prevention and Oncopharmacology, N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut Senchik K. Laboratory of Cancer Chemotherapeutic Prevention and Oncopharmacology, N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut Stukov A. Laboratory of Cancer Chemotherapeutic Prevention and Oncopharmacology, N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut Belyaev A. Laboratory of Cancer Chemotherapeutic Prevention and Oncopharmacology, N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 81-84 0007-4888 159:1<81 2015 159 10517 https://doi.org/10.1007/s10517-015-2895-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2895-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bespalov V. Laboratory of Cancer Chemotherapeutic Prevention and Oncopharmacology, N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Belyaeva O. Laboratory of Cancer Chemotherapeutic Prevention and Oncopharmacology, N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Kireeva G. Laboratory of Cancer Chemotherapeutic Prevention and Oncopharmacology, N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Senchik K. Laboratory of Cancer Chemotherapeutic Prevention and Oncopharmacology, N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Stukov A. Laboratory of Cancer Chemotherapeutic Prevention and Oncopharmacology, N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Belyaev A. Laboratory of Cancer Chemotherapeutic Prevention and Oncopharmacology, N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 81-84 0007-4888 159:1<81 2015 159 10517