Peptide Regulation of Cells Renewal Processes in Kidney Tissue Cultures from Young and Old Animals
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2906-9 |2 doi |
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| 245 | 0 | 0 | |a Peptide Regulation of Cells Renewal Processes in Kidney Tissue Cultures from Young and Old Animals |h [Elektronische Daten] |c [N. Chalisova, N. Lin'kova, T. Nichik, A. Ryzhak, A. Dudkov, G. Ryzhak] |
| 520 | 3 | |a Polypeptide complex isolated from calf kidneys stimulates the processes of cell renewal in organotypic kidney tissue cultures from young and old rats. The polypeptide complex enhances expression of proliferation marker Ki-67 and reduces expression of proapoptotic peptide p53 in kidney explants obtained from young and old animals. Short peptides T-31 (AED) and T-35 (EDL) also stimulate proliferation and reduce apoptosis of the kidney cells, but to a lesser degree than the polypeptide complex. The results provide the basis for further investigation of the polypeptide complex as a preparation for the therapy of kidney diseases, including age-related pathologies. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a polypeptide complex |2 nationallicence | |
| 690 | 7 | |a cell renewal |2 nationallicence | |
| 690 | 7 | |a organotypic cultures |2 nationallicence | |
| 690 | 7 | |a kidneys |2 nationallicence | |
| 690 | 7 | |a aging |2 nationallicence | |
| 700 | 1 | |a Chalisova |D N. |u St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Lin'kova |D N. |u St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Nichik |D T. |u St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Ryzhak |D A. |u St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Dudkov |D A. |u St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Ryzhak |D G. |u St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/1(2015-05-01), 124-127 |x 0007-4888 |q 159:1<124 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2906-9 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2906-9 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chalisova |D N. |u St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lin'kova |D N. |u St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nichik |D T. |u St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ryzhak |D A. |u St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Dudkov |D A. |u St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ryzhak |D G. |u St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/1(2015-05-01), 124-127 |x 0007-4888 |q 159:1<124 |1 2015 |2 159 |o 10517 | ||