caa a22 4500 605535000 CHVBK 20210128100845.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10517-015-2906-9 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2906-9 Peptide Regulation of Cells Renewal Processes in Kidney Tissue Cultures from Young and Old Animals [Elektronische Daten] [N. Chalisova, N. Lin'kova, T. Nichik, A. Ryzhak, A. Dudkov, G. Ryzhak] Polypeptide complex isolated from calf kidneys stimulates the processes of cell renewal in organotypic kidney tissue cultures from young and old rats. The polypeptide complex enhances expression of proliferation marker Ki-67 and reduces expression of proapoptotic peptide p53 in kidney explants obtained from young and old animals. Short peptides T-31 (AED) and T-35 (EDL) also stimulate proliferation and reduce apoptosis of the kidney cells, but to a lesser degree than the polypeptide complex. The results provide the basis for further investigation of the polypeptide complex as a preparation for the therapy of kidney diseases, including age-related pathologies. Springer Science+Business Media New York, 2015 polypeptide complex nationallicence cell renewal nationallicence organotypic cultures nationallicence kidneys nationallicence aging nationallicence Chalisova N. St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia aut Lin'kova N. St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia aut Nichik T. St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia aut Ryzhak A. St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia aut Dudkov A. St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia aut Ryzhak G. St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 124-127 0007-4888 159:1<124 2015 159 10517 https://doi.org/10.1007/s10517-015-2906-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2906-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chalisova N. St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Lin'kova N. St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Nichik T. St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Ryzhak A. St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Dudkov A. St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Ryzhak G. St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 124-127 0007-4888 159:1<124 2015 159 10517