caa a22 4500 605535019 CHVBK 20210128100845.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10517-015-2890-0 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2890-0 Chrono- and Immunocorrection of Inflammatory Disorders of Internal Reproductive Organs in Women of Reproductive Age [Elektronische Daten] [G. Litvinenko, A. Shurlygina, T. Dergacheva, E. Mel'nikova, V. Trufakin] We compared the effectiveness of immunomodulators used in the treatment of patients with chronic salpingitis and oophoritis with or without changes in succinate dehydrogenase (SDH) activity in blood lymphocytes at incubation with the drug. Diurnal variations in individual reaction of SDH in blood lymphocytes to thymalin or ridostin were revealed. In the groups of women receiving ridostin or thymalin during the reaction of lymphocyte SDH to it, improvement of clinical laboratory and immunological parameters was observed in the majority of the patients and no effect was found in a lesser group of patients than in the groups treated with drugs during the absence of lymphocyte SDH reaction thereto. The timing of the presence of SDH reaction to drugs in the immunocompetent cells makes it possible to set the optimal daily regime of their application and to select a drug that would be most effective in each particular case. Springer Science+Business Media New York, 2015 chronic inflammation nationallicence immunomodulation nationallicence lymphocytes nationallicence chronotherapy nationallicence Litvinenko G. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut Shurlygina A. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut Dergacheva T. Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia aut Mel'nikova E. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut Trufakin V. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 62-65 0007-4888 159:1<62 2015 159 10517 https://doi.org/10.1007/s10517-015-2890-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2890-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Litvinenko G. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Shurlygina A. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Dergacheva T. Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Mel'nikova E. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Trufakin V. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 62-65 0007-4888 159:1<62 2015 159 10517