Activation of P-450-Dependent Monooxygenases Modulates the Diuretic Effect of Histochrome in Rats
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| 024 | 7 | 0 | |a 10.1007/s10517-015-3066-7 |2 doi |
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| 245 | 0 | 0 | |a Activation of P-450-Dependent Monooxygenases Modulates the Diuretic Effect of Histochrome in Rats |h [Elektronische Daten] |c [O. Talalaeva, V. Bryukhanov, Ya. Zverev, V. Lampatov, A. Zharikov, N. Mischenko, I. Sheremet'eva] |
| 520 | 3 | |a We studied the role of the liver monooxygenase system in pharmacological activity of histochrome, a pharmaceutical form of echinochrome A. In experiments on rats, benzonal, an inductor of the monooxygenase system of phenobarbytal type, significantly potentiated the diuretic effect of histochrome. Benzonal withdrawal was followed by a natriuretic reaction. In view of the known inverse relation between the biological effect of the drug and the rate of its metabolism, our findings suggest that the effects of echinochrome A on some kidney excretory function parameters are produced not by native agent, but one of its metabolites. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a histochrome |2 nationallicence | |
| 690 | 7 | |a benzonal |2 nationallicence | |
| 690 | 7 | |a microsomal oxidation |2 nationallicence | |
| 700 | 1 | |a Talalaeva |D O. |u Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia |4 aut | |
| 700 | 1 | |a Bryukhanov |D V. |u Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia |4 aut | |
| 700 | 1 | |a Zverev |D Ya |u Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia |4 aut | |
| 700 | 1 | |a Lampatov |D V. |u Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia |4 aut | |
| 700 | 1 | |a Zharikov |D A. |u Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia |4 aut | |
| 700 | 1 | |a Mischenko |D N. |u Pacific Institute of Bioorganic Chemistry, Far-East Division of the Russian Academy of Sciences, Vladivostok, Russia |4 aut | |
| 700 | 1 | |a Sheremet'eva |D I. |u Department of Psychiatry and Narcology, Altay State Medical University, Barnaul, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/6(2015-10-01), 750-752 |x 0007-4888 |q 159:6<750 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-3066-7 |q text/html |z Onlinezugriff via DOI |
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-3066-7 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Talalaeva |D O. |u Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Bryukhanov |D V. |u Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zverev |D Ya |u Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lampatov |D V. |u Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zharikov |D A. |u Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mischenko |D N. |u Pacific Institute of Bioorganic Chemistry, Far-East Division of the Russian Academy of Sciences, Vladivostok, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sheremet'eva |D I. |u Department of Psychiatry and Narcology, Altay State Medical University, Barnaul, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/6(2015-10-01), 750-752 |x 0007-4888 |q 159:6<750 |1 2015 |2 159 |o 10517 | ||