caa a22 4500 605535043 CHVBK 20210128100845.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10517-015-3066-7 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3066-7 Activation of P-450-Dependent Monooxygenases Modulates the Diuretic Effect of Histochrome in Rats [Elektronische Daten] [O. Talalaeva, V. Bryukhanov, Ya. Zverev, V. Lampatov, A. Zharikov, N. Mischenko, I. Sheremet'eva] We studied the role of the liver monooxygenase system in pharmacological activity of histochrome, a pharmaceutical form of echinochrome A. In experiments on rats, benzonal, an inductor of the monooxygenase system of phenobarbytal type, significantly potentiated the diuretic effect of histochrome. Benzonal withdrawal was followed by a natriuretic reaction. In view of the known inverse relation between the biological effect of the drug and the rate of its metabolism, our findings suggest that the effects of echinochrome A on some kidney excretory function parameters are produced not by native agent, but one of its metabolites. Springer Science+Business Media New York, 2015 histochrome nationallicence benzonal nationallicence microsomal oxidation nationallicence Talalaeva O. Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia aut Bryukhanov V. Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia aut Zverev Ya Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia aut Lampatov V. Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia aut Zharikov A. Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia aut Mischenko N. Pacific Institute of Bioorganic Chemistry, Far-East Division of the Russian Academy of Sciences, Vladivostok, Russia aut Sheremet'eva I. Department of Psychiatry and Narcology, Altay State Medical University, Barnaul, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/6(2015-10-01), 750-752 0007-4888 159:6<750 2015 159 10517 https://doi.org/10.1007/s10517-015-3066-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3066-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Talalaeva O. Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia aut NATIONALLICENCE 700 1- Bryukhanov V. Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia aut NATIONALLICENCE 700 1- Zverev Ya Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia aut NATIONALLICENCE 700 1- Lampatov V. Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia aut NATIONALLICENCE 700 1- Zharikov A. Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia aut NATIONALLICENCE 700 1- Mischenko N. Pacific Institute of Bioorganic Chemistry, Far-East Division of the Russian Academy of Sciences, Vladivostok, Russia aut NATIONALLICENCE 700 1- Sheremet'eva I. Department of Psychiatry and Narcology, Altay State Medical University, Barnaul, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/6(2015-10-01), 750-752 0007-4888 159:6<750 2015 159 10517