caa a22 4500 605535051 CHVBK 20210128100845.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10517-015-3062-y doi (NATIONALLICENCE)springer-10.1007/s10517-015-3062-y Peptides Restore Functional State of the Kidneys During Cisplatin-Induced Acute Renal Failure [Elektronische Daten] [I. Zamorskii, T. Shchudrova, N. Lin'kova, T. Nichik, V. Khavinson] The effects of polypeptide complex from the kidney and short peptides AED, EDL, and AEDG on renal functions were studied in rats with cisplatin-induced acute renal failure. AED peptide decreased protein excretion and electrolyte concentration in the urine. Polypeptide complex from the kidney and peptides EDL and AEDG normalized diuresis, creatinine concentration in the urine and its excretion, glomerular filtration rate, and absolute resorption of sodium ions and reduced protein concentration in the urine and its excretion, the concentrations of sodium and potassium ions in the urine, and other parameters. EDL peptide produced was potent nephroprotective effect. It is known that the polypeptide complex of the kidney and short peptides restore the expression of signal molecules (marker of functional state of the kidneys), so these peptide substances can have nephroprotective effect during various renal pathologies. Springer Science+Business Media New York, 2015 acute renal failure nationallicence cisplatin nationallicence peptides nationallicence Zamorskii I. Bukovinian State Medical University, Chernovtsy, Ukraine aut Shchudrova T. Bukovinian State Medical University, Chernovtsy, Ukraine aut Lin'kova N. St. Petersburg State Polytechnic University, St. Petersburg, Russia aut Nichik T. St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia aut Khavinson V. I. I. Mechnikov North-Western State Medical University, St. Petersburg, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/6(2015-10-01), 736-739 0007-4888 159:6<736 2015 159 10517 https://doi.org/10.1007/s10517-015-3062-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3062-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zamorskii I. Bukovinian State Medical University, Chernovtsy, Ukraine aut NATIONALLICENCE 700 1- Shchudrova T. Bukovinian State Medical University, Chernovtsy, Ukraine aut NATIONALLICENCE 700 1- Lin'kova N. St. Petersburg State Polytechnic University, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Nichik T. St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Khavinson V. I. I. Mechnikov North-Western State Medical University, St. Petersburg, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/6(2015-10-01), 736-739 0007-4888 159:6<736 2015 159 10517