Prospects of Using of κ-Opioid Receptor Agonists U-50,488 and ICI 199,441 for Improving Heart Resistance to Ischemia/Reperfusion
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| 024 | 7 | 0 | |a 10.1007/s10517-015-3057-8 |2 doi |
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| 245 | 0 | 0 | |a Prospects of Using of κ-Opioid Receptor Agonists U-50,488 and ICI 199,441 for Improving Heart Resistance to Ischemia/Reperfusion |h [Elektronische Daten] |c [S. Tsibulnikov, L. Maslov, A. Mukhomedzyanov, A. Krylatov, M. Tsibulnikova, Yu. Lishmanov] |
| 520 | 3 | |a We studied the ability of the agonist of κ1-opioid receptors U-50,488 in doses of 0.1 and 1 mg/kg to simulate ischemic pre- and postconditioning of the heart and κ-opioid receptors ICI 199,441 in a dose of 0.1 mg/kg to simulate the antiarrhythmic effect of heart preconditioning. The duration of ischemia was 10 or 45 min and the duration of reperfusion was 10 min or 2 h. Administration of 1 mg/kg U-50,488 both before ischemia and 5 min before reperfusion produced a pronounced antiarrhythmic effect. U-50,488 injected 5 min before reperfusion 2-fold reduced the ratio of infarction to risk area. Administration of ICI 199,441 in a dose of 0.1 mg/kg 15 min before ischemia produced a potent antiarrhythmic effect. Antiarrhythmic effect of κ-opioid receptor agonists depended on activation of κ-opioid receptors. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a heart |2 nationallicence | |
| 690 | 7 | |a reperfusion |2 nationallicence | |
| 690 | 7 | |a κ-opioid receptors |2 nationallicence | |
| 690 | 7 | |a postconditioning |2 nationallicence | |
| 700 | 1 | |a Tsibulnikov |D S. |u Research Institute of Cardiology, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Maslov |D L. |u Research Institute of Cardiology, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Mukhomedzyanov |D A. |u Research Institute of Cardiology, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Krylatov |D A. |u Research Institute of Cardiology, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Tsibulnikova |D M. |u National Research Tomsk Polytechnic University, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Lishmanov |D Yu |u Research Institute of Cardiology, Tomsk, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/6(2015-10-01), 718-721 |x 0007-4888 |q 159:6<718 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-3057-8 |q text/html |z Onlinezugriff via DOI |
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-3057-8 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tsibulnikov |D S. |u Research Institute of Cardiology, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Maslov |D L. |u Research Institute of Cardiology, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mukhomedzyanov |D A. |u Research Institute of Cardiology, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Krylatov |D A. |u Research Institute of Cardiology, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tsibulnikova |D M. |u National Research Tomsk Polytechnic University, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lishmanov |D Yu |u Research Institute of Cardiology, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/6(2015-10-01), 718-721 |x 0007-4888 |q 159:6<718 |1 2015 |2 159 |o 10517 | ||