caa a22 4500 60553506X CHVBK 20210128100845.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10517-015-3057-8 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3057-8 Prospects of Using of κ-Opioid Receptor Agonists U-50,488 and ICI 199,441 for Improving Heart Resistance to Ischemia/Reperfusion [Elektronische Daten] [S. Tsibulnikov, L. Maslov, A. Mukhomedzyanov, A. Krylatov, M. Tsibulnikova, Yu. Lishmanov] We studied the ability of the agonist of κ1-opioid receptors U-50,488 in doses of 0.1 and 1 mg/kg to simulate ischemic pre- and postconditioning of the heart and κ-opioid receptors ICI 199,441 in a dose of 0.1 mg/kg to simulate the antiarrhythmic effect of heart preconditioning. The duration of ischemia was 10 or 45 min and the duration of reperfusion was 10 min or 2 h. Administration of 1 mg/kg U-50,488 both before ischemia and 5 min before reperfusion produced a pronounced antiarrhythmic effect. U-50,488 injected 5 min before reperfusion 2-fold reduced the ratio of infarction to risk area. Administration of ICI 199,441 in a dose of 0.1 mg/kg 15 min before ischemia produced a potent antiarrhythmic effect. Antiarrhythmic effect of κ-opioid receptor agonists depended on activation of κ-opioid receptors. Springer Science+Business Media New York, 2015 heart nationallicence reperfusion nationallicence κ-opioid receptors nationallicence postconditioning nationallicence Tsibulnikov S. Research Institute of Cardiology, Tomsk, Russia aut Maslov L. Research Institute of Cardiology, Tomsk, Russia aut Mukhomedzyanov A. Research Institute of Cardiology, Tomsk, Russia aut Krylatov A. Research Institute of Cardiology, Tomsk, Russia aut Tsibulnikova M. National Research Tomsk Polytechnic University, Tomsk, Russia aut Lishmanov Yu Research Institute of Cardiology, Tomsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/6(2015-10-01), 718-721 0007-4888 159:6<718 2015 159 10517 https://doi.org/10.1007/s10517-015-3057-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3057-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tsibulnikov S. Research Institute of Cardiology, Tomsk, Russia aut NATIONALLICENCE 700 1- Maslov L. Research Institute of Cardiology, Tomsk, Russia aut NATIONALLICENCE 700 1- Mukhomedzyanov A. Research Institute of Cardiology, Tomsk, Russia aut NATIONALLICENCE 700 1- Krylatov A. Research Institute of Cardiology, Tomsk, Russia aut NATIONALLICENCE 700 1- Tsibulnikova M. National Research Tomsk Polytechnic University, Tomsk, Russia aut NATIONALLICENCE 700 1- Lishmanov Yu Research Institute of Cardiology, Tomsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/6(2015-10-01), 718-721 0007-4888 159:6<718 2015 159 10517