caa a22 4500 605535078 CHVBK 20210128100845.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10517-015-3074-7 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3074-7 Role of Interleukin-4, Interleukin-10, and Tumor Necrosis Factor-α Polymorphic Genes in the Pathogenesis of Occupational Allergic Dermatoses [Elektronische Daten] [L. Kuz'mina, N. Izmerova, M. Kolyaskina] Study of polymorphic genes of pro- and anti-inflammatory cytokines (IL-4, IL-10, TNF-α) in patients with occupational allergic dermatoses showed significantly higher frequency of polymorphic variants of cytokine genes IL4 C589T, IL10 C819T, IL10 G1082A, IL10 C592A, and TNF G308A in comparison with the population control. The presence of homozygous variant IL10 G1082A - AA in 80% cases characterizes early disease development, i.e. within 3 years after the first exposure to the occupational factor. Springer Science+Business Media New York, 2015 occupational allergic dermatoses nationallicence cytokines nationallicence individual liability nationallicence Kuz'mina L. Research Institute of Labor Medicine, Moscow, Russia aut Izmerova N. Research Institute of Labor Medicine, Moscow, Russia aut Kolyaskina M. Research Institute of Labor Medicine, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/6(2015-10-01), 779-781 0007-4888 159:6<779 2015 159 10517 https://doi.org/10.1007/s10517-015-3074-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3074-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kuz'mina L. Research Institute of Labor Medicine, Moscow, Russia aut NATIONALLICENCE 700 1- Izmerova N. Research Institute of Labor Medicine, Moscow, Russia aut NATIONALLICENCE 700 1- Kolyaskina M. Research Institute of Labor Medicine, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/6(2015-10-01), 779-781 0007-4888 159:6<779 2015 159 10517