Stimulation of Cardiomyocyte Regeneratory Reactions under Conditions of Cytopathic Hypercholesterolemia
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| 024 | 7 | 0 | |a 10.1007/s10517-015-3079-2 |2 doi |
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| 245 | 0 | 0 | |a Stimulation of Cardiomyocyte Regeneratory Reactions under Conditions of Cytopathic Hypercholesterolemia |h [Elektronische Daten] |c [E. Lushnikova, E. Yuzhik, M. Klinnikova, L. Nepomnyashchikh] |
| 520 | 3 | |a The regeneratory reactions of cardiomyocytes in the heart under conditions of cytopathic exposure to hypercholesterolemia and during verapamil treatment were studied by immunohistochemical detection of proliferation marker Ki-67 and evaluation of cardiomyocyte count. A 30-day exposure of rats to atherogenic diet led to an increase of Ki-67+ cardiomyocytes by 14.5-16.7 times (p<0.05). The Ki-67 label index in cardiomyocytes remained higher than normally (8-9-fold; p<0.05) after 64 days. It remained elevated (8-11-fold; p<0.05) after verapamil treatment. Evaluation of cardiomyocyte count and of their nuclear status detected various regeneratory strategies: increase of the total cardiomyocyte count, with increase of the percentage of mononuclear cardiomyocytes (particularly in response to verapamil in group 1 rats); decrease of total cardiomyocyte count with increase of the percentage of multinuclear cardiomyocytes (particularly in group 2 rats in response to verapamil). | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a hypercholesterolemia |2 nationallicence | |
| 690 | 7 | |a cardiomyocytes |2 nationallicence | |
| 690 | 7 | |a regeneration |2 nationallicence | |
| 690 | 7 | |a verapamil |2 nationallicence | |
| 690 | 7 | |a Ki-67 |2 nationallicence | |
| 700 | 1 | |a Lushnikova |D E. |u Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Yuzhik |D E. |u Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Klinnikova |D M. |u Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Nepomnyashchikh |D L. |u Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/6(2015-10-01), 796-800 |x 0007-4888 |q 159:6<796 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-3079-2 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-3079-2 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lushnikova |D E. |u Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yuzhik |D E. |u Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Klinnikova |D M. |u Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nepomnyashchikh |D L. |u Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/6(2015-10-01), 796-800 |x 0007-4888 |q 159:6<796 |1 2015 |2 159 |o 10517 | ||