caa a22 4500 605535124 CHVBK 20210128100846.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10517-015-3080-9 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3080-9 Morphology and Immunohistochemical Phenotype of the Thymus in Secondary Immunodeficiency [Elektronische Daten] [G. Struchko, L. Merkulova, E. Moskvichev, O. Kostrova, M. Mikhailova, E. Drandrova] The thymus of outbred male rats 5 months after splenectomy (experimental secondary immunodeficiency) was studied by common histological and immunohistochemical methods using monoclonal and polyclonal antibodies to CD3, CD30, CD68, synaptophysin, to S100, p53, bcl-2, and Ki-67 proteins. Removal of the spleen led to acute involution of the thymic parenchyma, which was replaced by the adipose tissue and was associated with restructuring of the thymopoietic and nonthymopoietic components of the gland, changes in cellular composition and antigenic phenotype of the lobular cortical and medullary matter, and by reduction of cell proliferation. Springer Science+Business Media New York, 2015 thymus nationallicence involution nationallicence splenectomy nationallicence immunodeficiency nationallicence Struchko G. Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University, Cheboksary, Russia aut Merkulova L. Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University, Cheboksary, Russia aut Moskvichev E. Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University, Cheboksary, Russia aut Kostrova O. Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University, Cheboksary, Russia aut Mikhailova M. Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University, Cheboksary, Russia aut Drandrova E. Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University, Cheboksary, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/6(2015-10-01), 801-804 0007-4888 159:6<801 2015 159 10517 https://doi.org/10.1007/s10517-015-3080-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3080-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Struchko G. Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University, Cheboksary, Russia aut NATIONALLICENCE 700 1- Merkulova L. Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University, Cheboksary, Russia aut NATIONALLICENCE 700 1- Moskvichev E. Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University, Cheboksary, Russia aut NATIONALLICENCE 700 1- Kostrova O. Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University, Cheboksary, Russia aut NATIONALLICENCE 700 1- Mikhailova M. Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University, Cheboksary, Russia aut NATIONALLICENCE 700 1- Drandrova E. Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University, Cheboksary, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/6(2015-10-01), 801-804 0007-4888 159:6<801 2015 159 10517