Effect of α7n-Acetylcholine Receptor Activation and Antibodies to TNF-α on Mortality of Mice and Concentration of Proinflammatory Cytokines During Early Stage of Sepsis
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| 024 | 7 | 0 | |a 10.1007/s10517-015-3063-x |2 doi |
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| 245 | 0 | 0 | |a Effect of α7n-Acetylcholine Receptor Activation and Antibodies to TNF-α on Mortality of Mice and Concentration of Proinflammatory Cytokines During Early Stage of Sepsis |h [Elektronische Daten] |c [P. Zabrodskii, M. Gromov, V. Maslyakov] |
| 520 | 3 | |a Experiments on random-bred albino mice showed that activation α7n-acetylcholine receptors with anabasine (0.5 LD50) and the use of antibodies to TNF-α (1 mg/kg) 2 h before sepsis modeling significantly reduces mortality of mice from experimental sepsis (intraperitoneal injection of E. coli) due to a decrease in the blood concentration of proinflammatory cytokines TNF-α, IL-1β, and IL-6. After combined administration of anti-TNF-α antibodies and anabasine, an additive effect was observed. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a cholinergic anti-inflammatory pathway |2 nationallicence | |
| 690 | 7 | |a sepsis |2 nationallicence | |
| 690 | 7 | |a α7n-acetylcholine receptors |2 nationallicence | |
| 690 | 7 | |a antibodies to TNF-α |2 nationallicence | |
| 690 | 7 | |a proinflammatory cytokines |2 nationallicence | |
| 700 | 1 | |a Zabrodskii |D P. |u Saratov Branch of Samara Medical Institute REAVIZ, Saratov, Russia |4 aut | |
| 700 | 1 | |a Gromov |D M. |u Saratov Branch of Samara Medical Institute REAVIZ, Saratov, Russia |4 aut | |
| 700 | 1 | |a Maslyakov |D V. |u Saratov Branch of Samara Medical Institute REAVIZ, Saratov, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/6(2015-10-01), 740-742 |x 0007-4888 |q 159:6<740 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-3063-x |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-3063-x |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zabrodskii |D P. |u Saratov Branch of Samara Medical Institute REAVIZ, Saratov, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gromov |D M. |u Saratov Branch of Samara Medical Institute REAVIZ, Saratov, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Maslyakov |D V. |u Saratov Branch of Samara Medical Institute REAVIZ, Saratov, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/6(2015-10-01), 740-742 |x 0007-4888 |q 159:6<740 |1 2015 |2 159 |o 10517 | ||