Effects of μ-Opioid Receptor Agonist DAMGO on Heart Contractility and Necrotic Injury to Cardiomyocytes during Ischemia and Reperfusion of Isolated Rat Heart
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| 024 | 7 | 0 | |a 10.1007/s10517-015-3058-7 |2 doi |
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| 245 | 0 | 0 | |a Effects of μ-Opioid Receptor Agonist DAMGO on Heart Contractility and Necrotic Injury to Cardiomyocytes during Ischemia and Reperfusion of Isolated Rat Heart |h [Elektronische Daten] |c [T. Lasukova, L. Maslov, A. Gorbunov] |
| 520 | 3 | |a We studied the effects of μ-opioid receptor activation in vivo and in vitro on the tolerance of isolated perfused rat heart to global ischemia (45 min) and reperfusion (30 min). Stimulation of μ-receptors in vivo by intraperitoneal administration of μ-opioid receptor agonist DAMGO (0.1 mg/kg) reduced reperfusion release of creatinine phosphokinase and promoted aggravation of postischemic systolic and diastolic dysfunction of the isolated heart. Activation of μ-opioid receptors in vitro by addition of selective agonist DAMGO in a concentration of 170 nM to perfusion solution had no effect on necrotic death of cardiomyocytes and aggravated reperfusion stunning of the heart. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a heart |2 nationallicence | |
| 690 | 7 | |a ischemia |2 nationallicence | |
| 690 | 7 | |a reperfusion |2 nationallicence | |
| 690 | 7 | |a opioid receptors |2 nationallicence | |
| 700 | 1 | |a Lasukova |D T. |u Department of Medical and Biological Disciplines, Tomsk State Pedagogical University, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Maslov |D L. |u Laboratory of Experimental Cardiology, Research Institute of Cardiology, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Gorbunov |D A. |u Laboratory of Experimental Cardiology, Research Institute of Cardiology, Tomsk, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/6(2015-10-01), 722-725 |x 0007-4888 |q 159:6<722 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-3058-7 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-3058-7 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lasukova |D T. |u Department of Medical and Biological Disciplines, Tomsk State Pedagogical University, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Maslov |D L. |u Laboratory of Experimental Cardiology, Research Institute of Cardiology, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gorbunov |D A. |u Laboratory of Experimental Cardiology, Research Institute of Cardiology, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/6(2015-10-01), 722-725 |x 0007-4888 |q 159:6<722 |1 2015 |2 159 |o 10517 | ||