caa a22 4500 605535183 CHVBK 20210128100846.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10517-015-3078-3 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3078-3 Effects of Inhibitors of Necroptosis and Autophagy on Morphofunctional Characteristics of the Myocardium during Static Cold Storage of Donor Rat Heart [Elektronische Daten] [Yu. Dmitriev, S. Minasyan, L. Vasina, E. Demchenko, M. Galagudza] Cardioprotective effects of necrostatin-1 (necroptosis inhibitor) and 3-methyladenine (autophagy inhibitor) were studied on the model of long-term cold preservation of rat heart. Addition of necrostatin-1 (490 nmol/liter) or 3-methyladenine (4.5 mmol/liter) to custodiol preserving solution reduced myocardial infarction size and improved left-ventricular function during reperfusion after 8-h preservation at 4°C. Inhibition of necroptosis and autophagy contributed to the cardioprotective effect under conditions of cold preservation of the donor heart. Springer Science+Business Media New York, 2015 necroptosis nationallicence autophagy nationallicence necrostatin-1 nationallicence 3-methyladenine nationallicence cold preservation nationallicence Dmitriev Yu North-Western Federal Medical Research Center, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut Minasyan S. North-Western Federal Medical Research Center, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut Vasina L. North-Western Federal Medical Research Center, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut Demchenko E. North-Western Federal Medical Research Center, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut Galagudza M. North-Western Federal Medical Research Center, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/6(2015-10-01), 792-795 0007-4888 159:6<792 2015 159 10517 https://doi.org/10.1007/s10517-015-3078-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3078-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dmitriev Yu North-Western Federal Medical Research Center, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Minasyan S. North-Western Federal Medical Research Center, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Vasina L. North-Western Federal Medical Research Center, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Demchenko E. North-Western Federal Medical Research Center, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Galagudza M. North-Western Federal Medical Research Center, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/6(2015-10-01), 792-795 0007-4888 159:6<792 2015 159 10517