caa a22 4500 605535205 CHVBK 20210128100846.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10517-015-3054-y doi (NATIONALLICENCE)springer-10.1007/s10517-015-3054-y Nociceptive Reactions in Rats during Repeated Stress Exposure [Elektronische Daten] [A. Kozlov, A. Abramova, V. Chekhlov, O. Grigorchuk, S. Pertsov] Changes in nociceptive sensitivity of rats with various behavioral patterns in the open-field test were studied after repeated stress exposure on the model of daily 4-h immobilization for 8 days. The tail-flick latency in response to light-heat stimulation in passive and active specimens decreased most significantly on days 2 and 7, respectively. However, this parameter did not differ from the baseline on day 8 of observations. Vocalization threshold during electrocutaneous stimulation in behaviorally active animals did not change over the first 7 days of repeated stress exposure, but increased significantly on day 8 of the study. The emotional component of nociception in passive animals increased on day 3, but decreased on days 4 and 6 of the experiment. Therefore, repeated stress exposure in rats is mainly accompanied by an increase in the perceptual component of nociception. Variations in the emotional component of nociceptive sensitivity after stress loads are manifested in the initial increase and subsequent decrease in this parameter. The observed changes are more pronounced in behaviorally passive rats than in active animals. These data illustrate the specifics of stress-induced changes in nociception of specimens with various individual and typological characteristics. Our results hold much promise for the development of new individual approaches to modulation of pain sensitivity in humans under conditions of negative emotiogenic exposures. Springer Science+Business Media New York, 2015 rats nationallicence repeated stress exposure nationallicence emotional and perceptual components of nociception nationallicence Kozlov A. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russian Federation aut Abramova A. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russian Federation aut Chekhlov V. A. I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of the Russian Federation, Moscow, Russia aut Grigorchuk O. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russian Federation aut Pertsov S. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russian Federation aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/6(2015-10-01), 708-711 0007-4888 159:6<708 2015 159 10517 https://doi.org/10.1007/s10517-015-3054-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3054-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kozlov A. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russian Federation aut NATIONALLICENCE 700 1- Abramova A. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russian Federation aut NATIONALLICENCE 700 1- Chekhlov V. A. I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Grigorchuk O. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russian Federation aut NATIONALLICENCE 700 1- Pertsov S. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russian Federation aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/6(2015-10-01), 708-711 0007-4888 159:6<708 2015 159 10517