caa a22 4500 605535221 CHVBK 20210128100846.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10517-015-3065-8 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3065-8 Radioprotective Properties of Indralin in Combination with Monizol in the Treatment of Local Acute and Delayed Radiation Injuries Caused by Local Skin γ-Irradiation [Elektronische Daten] [M. Vasin, I. Ushakov, V. Kovtun, L. Semenova, S. Komarova, A. Galkin, R. Afanas'ev] Female rats were exposed to local γ-irradiation of the right hindpaw in doses of 30-50 Gy at 131-154 sGy/min dose rate. Radioprotector indralin was administered per os 15 min prior to irradiation, monizol was injected intraperitoneally 5 min after irradiation. Indralin showed marked radioprotective properties both for acute and delayed symptoms of local radiation injuries. In combination with monizol, radioprotective effect of indralin was potentiated to dose reduction factor of 1.4-1.5 both for radiation burn severity reduction and for restriction of postradiational contracture development and amputation of the irradiated limb. Springer Science+Business Media New York, 2015 Radioprotector nationallicence indralin nationallicence nitric oxide nationallicence skin radiation burn nationallicence postradiational fibrosis nationallicence Vasin M. State Scientific Center Institute of Medical and Biological Problems, Russian Academy of Sciences, Moscow, Russia aut Ushakov I. State Scientific Center Institute of Medical and Biological Problems, Russian Academy of Sciences, Moscow, Russia aut Kovtun V. State Scientific Center Institute of Medical and Biological Problems, Russian Academy of Sciences, Moscow, Russia aut Semenova L. State Scientific Center Institute of Medical and Biological Problems, Russian Academy of Sciences, Moscow, Russia aut Komarova S. State Scientific Center Institute of Medical and Biological Problems, Russian Academy of Sciences, Moscow, Russia aut Galkin A. State Scientific Center Institute of Medical and Biological Problems, Russian Academy of Sciences, Moscow, Russia aut Afanas'ev R. State Scientific Center Institute of Medical and Biological Problems, Russian Academy of Sciences, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/6(2015-10-01), 747-749 0007-4888 159:6<747 2015 159 10517 https://doi.org/10.1007/s10517-015-3065-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3065-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vasin M. State Scientific Center Institute of Medical and Biological Problems, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Ushakov I. State Scientific Center Institute of Medical and Biological Problems, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Kovtun V. State Scientific Center Institute of Medical and Biological Problems, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Semenova L. State Scientific Center Institute of Medical and Biological Problems, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Komarova S. State Scientific Center Institute of Medical and Biological Problems, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Galkin A. State Scientific Center Institute of Medical and Biological Problems, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Afanas'ev R. State Scientific Center Institute of Medical and Biological Problems, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/6(2015-10-01), 747-749 0007-4888 159:6<747 2015 159 10517