Sex-Related Differences in the Sensitivity to Carcinogenic Effect of Urethane on the Lungs in Mice Are Reversed after Neonatal Androgenization
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| 024 | 7 | 0 | |a 10.1007/s10517-015-3075-6 |2 doi |
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| 245 | 0 | 0 | |a Sex-Related Differences in the Sensitivity to Carcinogenic Effect of Urethane on the Lungs in Mice Are Reversed after Neonatal Androgenization |h [Elektronische Daten] |c [T. Morozkova, V. Kaledin] |
| 520 | 3 | |a Experiments on male and female CC57BR/Mv mice differing by the sensitivity to carcinogenic effect of urethane on the lungs showed that castration 1 week before carcinogen challenge reduced the number of lung adenomas caused by it in males and somewhat increased the number of tumors in females. Exogenous testosterone after urethane injection caused virtually no changes in urethane effect in males and females. By contrast, elevation of testosterone concentrations in newborn male and female mice by injections or its decrease in feminized males receiving sodium glutamate during the neonatal period reduced the sensitivity to the carcinogenic effect of urethane in adult males and to its increase in females. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a induced pulmonary adenomas |2 nationallicence | |
| 690 | 7 | |a gonadectomy |2 nationallicence | |
| 690 | 7 | |a neonatal androgenization |2 nationallicence | |
| 690 | 7 | |a sexrelated differences in urethane sensitivity |2 nationallicence | |
| 700 | 1 | |a Morozkova |D T. |u Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Kaledin |D V. |u nstitute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/6(2015-10-01), 782-785 |x 0007-4888 |q 159:6<782 |1 2015 |2 159 |o 10517 | |
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-3075-6 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Morozkova |D T. |u Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kaledin |D V. |u nstitute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/6(2015-10-01), 782-785 |x 0007-4888 |q 159:6<782 |1 2015 |2 159 |o 10517 | ||