caa a22 4500 605535280 CHVBK 20210128100846.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10517-015-3075-6 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3075-6 Sex-Related Differences in the Sensitivity to Carcinogenic Effect of Urethane on the Lungs in Mice Are Reversed after Neonatal Androgenization [Elektronische Daten] [T. Morozkova, V. Kaledin] Experiments on male and female CC57BR/Mv mice differing by the sensitivity to carcinogenic effect of urethane on the lungs showed that castration 1 week before carcinogen challenge reduced the number of lung adenomas caused by it in males and somewhat increased the number of tumors in females. Exogenous testosterone after urethane injection caused virtually no changes in urethane effect in males and females. By contrast, elevation of testosterone concentrations in newborn male and female mice by injections or its decrease in feminized males receiving sodium glutamate during the neonatal period reduced the sensitivity to the carcinogenic effect of urethane in adult males and to its increase in females. Springer Science+Business Media New York, 2015 induced pulmonary adenomas nationallicence gonadectomy nationallicence neonatal androgenization nationallicence sexrelated differences in urethane sensitivity nationallicence Morozkova T. Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia aut Kaledin V. nstitute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/6(2015-10-01), 782-785 0007-4888 159:6<782 2015 159 10517 https://doi.org/10.1007/s10517-015-3075-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3075-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Morozkova T. Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Kaledin V. nstitute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/6(2015-10-01), 782-785 0007-4888 159:6<782 2015 159 10517