Responses of Spermatogenous Tissue and Mechanisms of Their Development Upon Cytostatic Exposure
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| 024 | 7 | 0 | |a 10.1007/s10517-015-3064-9 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-3064-9 | ||
| 245 | 0 | 0 | |a Responses of Spermatogenous Tissue and Mechanisms of Their Development Upon Cytostatic Exposure |h [Elektronische Daten] |c [A. Dygai, A. Chaikovskii, V. Zhdanov, G. Zyuz'kov, L. Stavrova, V. Udut, L. Miroshnichenko, E. Simanina, T. Borovskaya, M. Poluektova] |
| 520 | 3 | |a A decrease in the total number of sperm cells and reduction of spermatogonium population were observed upon cytostatic damage of spermatogenous tissue caused by single paclitaxel administration. It was established that the paclitaxel-induced damage to the testicular tissue is underlain by reduction of its regenerative potential consisting in depletion of regional precursor pool. Changes in functional activity of progenitor cells were caused not only by direct action of paclitaxel, but also by suppression of the secretory function of the tissue microenvironment. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a spermatogenous tissue |2 nationallicence | |
| 690 | 7 | |a Sertoli cells |2 nationallicence | |
| 690 | 7 | |a progenitor cells |2 nationallicence | |
| 690 | 7 | |a regenerative medicine |2 nationallicence | |
| 690 | 7 | |a paclitaxel |2 nationallicence | |
| 700 | 1 | |a Dygai |D A. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Chaikovskii |D A. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Zhdanov |D V. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Zyuz'kov |D G. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Stavrova |D L. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Udut |D V. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Miroshnichenko |D L. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Simanina |D E. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Borovskaya |D T. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Poluektova |D M. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/6(2015-10-01), 743-746 |x 0007-4888 |q 159:6<743 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-3064-9 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-3064-9 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Dygai |D A. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chaikovskii |D A. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zhdanov |D V. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zyuz'kov |D G. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Stavrova |D L. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Udut |D V. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Miroshnichenko |D L. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Simanina |D E. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Borovskaya |D T. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Poluektova |D M. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/6(2015-10-01), 743-746 |x 0007-4888 |q 159:6<743 |1 2015 |2 159 |o 10517 | ||