caa a22 4500 605535302 CHVBK 20210128100847.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10517-015-3064-9 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3064-9 Responses of Spermatogenous Tissue and Mechanisms of Their Development Upon Cytostatic Exposure [Elektronische Daten] [A. Dygai, A. Chaikovskii, V. Zhdanov, G. Zyuz'kov, L. Stavrova, V. Udut, L. Miroshnichenko, E. Simanina, T. Borovskaya, M. Poluektova] A decrease in the total number of sperm cells and reduction of spermatogonium population were observed upon cytostatic damage of spermatogenous tissue caused by single paclitaxel administration. It was established that the paclitaxel-induced damage to the testicular tissue is underlain by reduction of its regenerative potential consisting in depletion of regional precursor pool. Changes in functional activity of progenitor cells were caused not only by direct action of paclitaxel, but also by suppression of the secretory function of the tissue microenvironment. Springer Science+Business Media New York, 2015 spermatogenous tissue nationallicence Sertoli cells nationallicence progenitor cells nationallicence regenerative medicine nationallicence paclitaxel nationallicence Dygai A. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Chaikovskii A. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Zhdanov V. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Zyuz'kov G. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Stavrova L. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Udut V. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Miroshnichenko L. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Simanina E. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Borovskaya T. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Poluektova M. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/6(2015-10-01), 743-746 0007-4888 159:6<743 2015 159 10517 https://doi.org/10.1007/s10517-015-3064-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3064-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dygai A. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 700 1- Chaikovskii A. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 700 1- Zhdanov V. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 700 1- Zyuz'kov G. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 700 1- Stavrova L. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 700 1- Udut V. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 700 1- Miroshnichenko L. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 700 1- Simanina E. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 700 1- Borovskaya T. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 700 1- Poluektova M. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/6(2015-10-01), 743-746 0007-4888 159:6<743 2015 159 10517