caa a22 4500 605535329 CHVBK 20210128100847.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10517-015-3069-4 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3069-4 Effects of Geroprotectors on Age-Related Changes in Proteolytic Digestive Enzyme Activities at Different Lighting Conditions [Elektronische Daten] [A. Morozov, E. Khizhkin, E. Svechkina, I. Vinogradova, V. Ilyukha, V. Anisimov, V. Khavinson] We studied the effect of melatonin and epithalon on age-related changes in proteolytic digestive enzyme activity in the pancreas and gastric mucosa of rats kept under different lighting conditions. In rats kept under standard illumination, pepsin activity and the total proteolytic activity in the stomach and pancreas increased by the age of 12 months, but then decreased. Constant and natural lighting disturbed the age dynamics of proteolytic digestive enzyme activity. Administration of melatonin and epithalon to animals exposed to constant lighting restored age dynamics of pepsin activity and little affected total proteolytic activity. Springer Science+Business Media New York, 2015 proteolytic digestive enzymes nationallicence melatonin nationallicence epithalon nationallicence illumination regimes nationallicence aging nationallicence Morozov A. Institute of Biology, Karelian Research Center, Russian Academy of Sciences, St. Petersburg, Russia aut Khizhkin E. Institute of Biology, Karelian Research Center, Russian Academy of Sciences, St. Petersburg, Russia aut Svechkina E. Institute of Biology, Karelian Research Center, Russian Academy of Sciences, St. Petersburg, Russia aut Vinogradova I. Petrozavodsk State University, Petrozavodsk, Republic of Karelia aut Ilyukha V. Institute of Biology, Karelian Research Center, Russian Academy of Sciences, St. Petersburg, Russia aut Anisimov V. N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut Khavinson V. St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/6(2015-10-01), 761-763 0007-4888 159:6<761 2015 159 10517 https://doi.org/10.1007/s10517-015-3069-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3069-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Morozov A. Institute of Biology, Karelian Research Center, Russian Academy of Sciences, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Khizhkin E. Institute of Biology, Karelian Research Center, Russian Academy of Sciences, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Svechkina E. Institute of Biology, Karelian Research Center, Russian Academy of Sciences, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Vinogradova I. Petrozavodsk State University, Petrozavodsk, Republic of Karelia aut NATIONALLICENCE 700 1- Ilyukha V. Institute of Biology, Karelian Research Center, Russian Academy of Sciences, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Anisimov V. N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Khavinson V. St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/6(2015-10-01), 761-763 0007-4888 159:6<761 2015 159 10517