caa a22 4500 605535353 CHVBK 20210128100847.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10517-015-3061-z doi (NATIONALLICENCE)springer-10.1007/s10517-015-3061-z Effects of Melatonin on Morphological and Functional Parameters of the Pineal Gland and Organs of Immune System in Rats During Natural Light Cycle and Constant Illumination [Elektronische Daten] [G. Litvinenko, A. Shurlygina, O. Gritsyk, E. Mel'nikova, M. Tenditnik, P. Avrorov, V. Trufakin] We studied the response of the pineal gland and organs of the immune system to melatonin treatment in Wistar rats kept under conditions of abnormal illumination regimen. The animals were kept under natural light regimen or continuous illumination for 14 days and then received daily injections of melatonin (once a day in the evening) for 7 days. Administration of melatonin to rats kept at natural light cycle was followed by a decrease in percent ratio of CD4+8+ splenocytes and CD4-8+ thymocytes. In 24-h light with the following melatonin injections were accompanied by an increase in percent rate and absolute amount of CD4+8+ cells in the spleen, and a decrease in percent rate of CD11b/c and CD4-8+ splenocytes. In the thymus amount of CD4-8+ cells increased, and absolute number of CD4+25+ cells reduced. Melatonin significantly decreased lipofuscin concentration in the pineal gland during continuous light. Direction and intensity of effects of melatonin on parameters of cell immunity and state of the pineal gland were different under normal and continuous light conditions. It should be taken into account during using of this hormone for correction of immune and endocrine impairments developing during change in light/dark rhythm. Springer Science+Business Media New York, 2015 lymphocytes nationallicence melatonin nationallicence pineal gland nationallicence lipofuscin nationallicence Litvinenko G. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut Shurlygina A. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut Gritsyk O. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut Mel'nikova E. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut Tenditnik M. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut Avrorov P. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut Trufakin V. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/6(2015-10-01), 732-735 0007-4888 159:6<732 2015 159 10517 https://doi.org/10.1007/s10517-015-3061-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3061-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Litvinenko G. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Shurlygina A. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Gritsyk O. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Mel'nikova E. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Tenditnik M. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Avrorov P. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Trufakin V. Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/6(2015-10-01), 732-735 0007-4888 159:6<732 2015 159 10517