Effects of a New Glutamic Acid Derivative on Myocardial Contractility of Stressed Animals under Conditions of Nitric Oxide Synthesis Blockade
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2969-7 |2 doi |
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| 245 | 0 | 0 | |a Effects of a New Glutamic Acid Derivative on Myocardial Contractility of Stressed Animals under Conditions of Nitric Oxide Synthesis Blockade |h [Elektronische Daten] |c [I. Tyurenkov, V. Perfilova, N. Sadikova, V. Berestovitskaya, O. Vasil'eva] |
| 520 | 3 | |a Glufimet (glutamic acid derivative) in a dose of 28.7 mg/kg limited the reduction of the cardiac functional reserve in animals subjected to 24-h stress under conditions of nonselective NO synthase blockade with L-NAME (10 mg/kg). Adrenoreactivity and increased afterload tests showed that the increment of myocardial contraction/relaxation rates, left-ventricular pressure, and HR were significantly higher in glufimet-treated stressed animals with NO synthesis blockade than in animals which received no glufimet. The efficiency of glufimet was higher than that of phenibut (the reference drug). | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a stress |2 nationallicence | |
| 690 | 7 | |a myocardial contractility |2 nationallicence | |
| 690 | 7 | |a nitric oxide |2 nationallicence | |
| 690 | 7 | |a glutamic acid |2 nationallicence | |
| 700 | 1 | |a Tyurenkov |D I. |u Volgograd State Medical University, Volgograd, Russia |4 aut | |
| 700 | 1 | |a Perfilova |D V. |u Volgograd State Medical University, Volgograd, Russia |4 aut | |
| 700 | 1 | |a Sadikova |D N. |u Volgograd State Medical University, Volgograd, Russia |4 aut | |
| 700 | 1 | |a Berestovitskaya |D V. |u Volgograd State Medical University, Volgograd, Russia |4 aut | |
| 700 | 1 | |a Vasil'eva |D O. |u Volgograd State Medical University, Volgograd, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/3(2015-07-01), 384-386 |x 0007-4888 |q 159:3<384 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2969-7 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2969-7 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tyurenkov |D I. |u Volgograd State Medical University, Volgograd, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Perfilova |D V. |u Volgograd State Medical University, Volgograd, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sadikova |D N. |u Volgograd State Medical University, Volgograd, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Berestovitskaya |D V. |u Volgograd State Medical University, Volgograd, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Vasil'eva |D O. |u Volgograd State Medical University, Volgograd, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/3(2015-07-01), 384-386 |x 0007-4888 |q 159:3<384 |1 2015 |2 159 |o 10517 | ||