Nootropic Effects of Filipendula Vulgaris Moench Water Extract Fractions
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2967-9 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-2967-9 | ||
| 245 | 0 | 0 | |a Nootropic Effects of Filipendula Vulgaris Moench Water Extract Fractions |h [Elektronische Daten] |c [I. Shilova, N. Suslov, V. Amelchenko] |
| 520 | 3 | |a Nootropic activity of water extract fractions from aerial parts of Filipendula vulgaris Moench was demonstrated on the models of hermetic volume hypoxia, conditioned passive avoidance response, open field test, and forced swimming with a load. The fractions stimulated hypoxic resistance, normalized orientation and exploratory behavior, improved conditioned response reproduction during testing after hypoxic injury, and increased exercise tolerance. Fractionation of the extract led to dissociation of the effect components, which suggests that individual constituents have specifi c characteristics. Ethylacetate fraction exhibited most pronounced nootropic activity and was superior to plant extract by some characteristics. The detected effects seemed to be caused by modulation of the hippocampus activity the under the effects of phenol and triterpene compounds. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Filipendula vulgaris Moench fractions |2 nationallicence | |
| 690 | 7 | |a conditioned passive avoidance response |2 nationallicence | |
| 690 | 7 | |a open-field test |2 nationallicence | |
| 690 | 7 | |a hypoxia |2 nationallicence | |
| 690 | 7 | |a forced swimming |2 nationallicence | |
| 700 | 1 | |a Shilova |D I. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Suslov |D N. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Amelchenko |D V. |u National Research Tomsk State University, Tomsk, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/3(2015-07-01), 376-379 |x 0007-4888 |q 159:3<376 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2967-9 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2967-9 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shilova |D I. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Suslov |D N. |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Amelchenko |D V. |u National Research Tomsk State University, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/3(2015-07-01), 376-379 |x 0007-4888 |q 159:3<376 |1 2015 |2 159 |o 10517 | ||