caa a22 4500 60553537X CHVBK 20210128100847.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10517-015-2967-9 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2967-9 Nootropic Effects of Filipendula Vulgaris Moench Water Extract Fractions [Elektronische Daten] [I. Shilova, N. Suslov, V. Amelchenko] Nootropic activity of water extract fractions from aerial parts of Filipendula vulgaris Moench was demonstrated on the models of hermetic volume hypoxia, conditioned passive avoidance response, open field test, and forced swimming with a load. The fractions stimulated hypoxic resistance, normalized orientation and exploratory behavior, improved conditioned response reproduction during testing after hypoxic injury, and increased exercise tolerance. Fractionation of the extract led to dissociation of the effect components, which suggests that individual constituents have specifi c characteristics. Ethylacetate fraction exhibited most pronounced nootropic activity and was superior to plant extract by some characteristics. The detected effects seemed to be caused by modulation of the hippocampus activity the under the effects of phenol and triterpene compounds. Springer Science+Business Media New York, 2015 Filipendula vulgaris Moench fractions nationallicence conditioned passive avoidance response nationallicence open-field test nationallicence hypoxia nationallicence forced swimming nationallicence Shilova I. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Suslov N. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Amelchenko V. National Research Tomsk State University, Tomsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 376-379 0007-4888 159:3<376 2015 159 10517 https://doi.org/10.1007/s10517-015-2967-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2967-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shilova I. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Suslov N. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Amelchenko V. National Research Tomsk State University, Tomsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 376-379 0007-4888 159:3<376 2015 159 10517