Expression of HIF-1α in Multipotent Mesenchymal Stromal Cells under Hypoxic Conditions

Verfasser / Beitragende:
[M. Pogodina, L. Buravkova]
Ort, Verlag, Jahr:
2015
Enthalten in:
Bulletin of Experimental Biology and Medicine, 159/3(2015-07-01), 355-357
Format:
Artikel (online)
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024 7 0 |a 10.1007/s10517-015-2961-2  |2 doi 
035 |a (NATIONALLICENCE)springer-10.1007/s10517-015-2961-2 
245 0 0 |a Expression of HIF-1α in Multipotent Mesenchymal Stromal Cells under Hypoxic Conditions  |h [Elektronische Daten]  |c [M. Pogodina, L. Buravkova] 
520 3 |a According to the data of reverse-transcription-PCR, long-term culturing of multipotent mesenchymal stromal cells from human adipose tissue at 1% O2 (vs. standard 20% O2) led to a decrease in HIF-1α gene expression, while no changes in this parameter were revealed at 5% O2. Analysis of the time course of HIF-1α mRNA level showed that at the early terms of hypoxic exposure, the expression of this gene increased and the duration of this increase depended on the severity of hypoxia. 
540 |a Springer Science+Business Media New York, 2015 
690 7 |a multipotent mesenchymal stromal cells  |2 nationallicence 
690 7 |a HIF-1α  |2 nationallicence 
690 7 |a gene expression  |2 nationallicence 
690 7 |a hypoxia  |2 nationallicence 
700 1 |a Pogodina  |D M.  |u State Scientific Center Institute of Biomedical Problems, Russian Academy of Medical Sciences, Moscow, Russia  |4 aut 
700 1 |a Buravkova  |D L.  |u State Scientific Center Institute of Biomedical Problems, Russian Academy of Medical Sciences, Moscow, Russia  |4 aut 
773 0 |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 159/3(2015-07-01), 355-357  |x 0007-4888  |q 159:3<355  |1 2015  |2 159  |o 10517 
856 4 0 |u https://doi.org/10.1007/s10517-015-2961-2  |q text/html  |z Onlinezugriff via DOI 
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900 7 |a Metadata rights reserved  |b Springer special CC-BY-NC licence  |2 nationallicence 
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950 |B NATIONALLICENCE  |P 700  |E 1-  |a Pogodina  |D M.  |u State Scientific Center Institute of Biomedical Problems, Russian Academy of Medical Sciences, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Buravkova  |D L.  |u State Scientific Center Institute of Biomedical Problems, Russian Academy of Medical Sciences, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 773  |E 0-  |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 159/3(2015-07-01), 355-357  |x 0007-4888  |q 159:3<355  |1 2015  |2 159  |o 10517