caa a22 4500 605535434 CHVBK 20210128100847.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10517-015-2963-0 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2963-0 Possible Recovery of Manifestation of Prolactin Receptor and Some of Its Target Proteins in the Liver and Kidney Cells of Female Rats after Relief of Cholestasis Complicated and Not Complicated by Hyperprolactinemia [Elektronische Daten] [M. Aleksandrova, N. Sirotina, O. Smirnova] Immunohistochemistry with semi-quantitative analysis of computer images showed that prolactin receptor and cystic fi brosis transmembrane regulator (CFTR) in cholangiocytes of female rats elevated in cholestasis quickly respond to its relief. The effect of hyperprolactinemia on the extent of return of these proteins to baseline was different. Decompression of the bile duct abolishes the negative effect of hyperprolactinemia on CFTR expression and its positive effect on mrp3 expression in the proximal renal tubules. In renal medulla, mrp2 expression decreased when cholestasis was induced against the background of hyperprolactinemia and increases after its removal. Prolactin receptors and CFTR in cholangiocytes are most susceptible to the decrease in bile duct pressure. Changes in the expression of the studied proteins after cholestasis relief are apparently associated with attenuated toxicity of the products removed by the kidneys, which abolishes the effects of prolactin. Springer Science+Business Media New York, 2015 prolactin receptor in rat liver and kidney nationallicence transmembrane regulator of cystic fibrosis nationallicence multidrug resistance proteins 2 and 3 nationallicence cholestasis relief nationallicence hyperprolactinemia nationallicence Aleksandrova M. Laboratory of Endocrinology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut Sirotina N. Laboratory of Endocrinology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut Smirnova O. Laboratory of Endocrinology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 361-364 0007-4888 159:3<361 2015 159 10517 https://doi.org/10.1007/s10517-015-2963-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2963-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Aleksandrova M. Laboratory of Endocrinology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut NATIONALLICENCE 700 1- Sirotina N. Laboratory of Endocrinology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut NATIONALLICENCE 700 1- Smirnova O. Laboratory of Endocrinology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 361-364 0007-4888 159:3<361 2015 159 10517