caa a22 4500 605535442 CHVBK 20210128100847.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10517-015-2955-0 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2955-0 Proliferative and Synthetic Activity of Nerve Cells after Combined or Individual Exposure to Hypoxia and Hypercapnia [Elektronische Daten] [P. Tregub, V. Kulikov, N. Rucheikin, E. Belova, Yu. Motin] We compared synthetic and proliferative activity of brain cells in rats exposed hypoxia, hypercapnia, or both prior to experimental focal stroke. The mean number of nucleolus organizer regions in penumbra neurons did not change after normobaric hypoxia, but increased after permissive hypercapnia or hypercapnic hypoxia. These data attest to activation of proliferative and synthetic functions in nerve cells, which plays an important role in the neuroprotective mechanisms under conditions of combined exposure to hypoxia and hypercapnia. Springer Science+Business Media New York, 2015 hypoxia nationallicence hypercapnia nationallicence stroke nationallicence brain nationallicence nucleolus organizer region nationallicence Tregub P. Ministry of Health of the Russian Federation, Altai State Medical University, Barnaul, Russia aut Kulikov V. Ministry of Health of the Russian Federation, Altai State Medical University, Barnaul, Russia aut Rucheikin N. Ministry of Health of the Russian Federation, Altai State Medical University, Barnaul, Russia aut Belova E. Ministry of Health of the Russian Federation, Altai State Medical University, Barnaul, Russia aut Motin Yu Ministry of Health of the Russian Federation, Altai State Medical University, Barnaul, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 334-336 0007-4888 159:3<334 2015 159 10517 https://doi.org/10.1007/s10517-015-2955-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2955-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tregub P. Ministry of Health of the Russian Federation, Altai State Medical University, Barnaul, Russia aut NATIONALLICENCE 700 1- Kulikov V. Ministry of Health of the Russian Federation, Altai State Medical University, Barnaul, Russia aut NATIONALLICENCE 700 1- Rucheikin N. Ministry of Health of the Russian Federation, Altai State Medical University, Barnaul, Russia aut NATIONALLICENCE 700 1- Belova E. Ministry of Health of the Russian Federation, Altai State Medical University, Barnaul, Russia aut NATIONALLICENCE 700 1- Motin Yu Ministry of Health of the Russian Federation, Altai State Medical University, Barnaul, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 334-336 0007-4888 159:3<334 2015 159 10517