Effects of Melatonin on Stress-Induced Changes in the Liver of Rats with Different Resistance to Stress

Verfasser / Beitragende:
[V. Serikov, Yu. Lyashev]
Ort, Verlag, Jahr:
2015
Enthalten in:
Bulletin of Experimental Biology and Medicine, 159/3(2015-07-01), 314-317
Format:
Artikel (online)
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024 7 0 |a 10.1007/s10517-015-2950-5  |2 doi 
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245 0 0 |a Effects of Melatonin on Stress-Induced Changes in the Liver of Rats with Different Resistance to Stress  |h [Elektronische Daten]  |c [V. Serikov, Yu. Lyashev] 
520 3 |a Effects of melatonin on changes in the liver structures were studied in stress-resistant and stress-sensitive rats exposed to chronic stress. It was found that the number of degenerative cells increased and intralobular sinusoidal capillary enlarged in the liver of animals of both groups. These parameters were significantly higher in stress-sensitive rats. Melatonin (1 mg/kg) reduced the severity of degenerative changes and stimulated the development of reparative processes in the liver tissue. The effects of the hormone was more pronounced in rats sensitive to stress and was noted after melatonin administration in a dose of 0.2 mg/kg. 
540 |a Springer Science+Business Media New York, 2015 
690 7 |a liver  |2 nationallicence 
690 7 |a chronic stress  |2 nationallicence 
690 7 |a melatonin  |2 nationallicence 
700 1 |a Serikov  |D V.  |u Department of Pathophysiology, Kursk State Medical University, Kursk, Russia  |4 aut 
700 1 |a Lyashev  |D Yu  |u Department of Pathophysiology, Kursk State Medical University, Kursk, Russia  |4 aut 
773 0 |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 159/3(2015-07-01), 314-317  |x 0007-4888  |q 159:3<314  |1 2015  |2 159  |o 10517 
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950 |B NATIONALLICENCE  |P 700  |E 1-  |a Serikov  |D V.  |u Department of Pathophysiology, Kursk State Medical University, Kursk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Lyashev  |D Yu  |u Department of Pathophysiology, Kursk State Medical University, Kursk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 773  |E 0-  |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 159/3(2015-07-01), 314-317  |x 0007-4888  |q 159:3<314  |1 2015  |2 159  |o 10517