caa a22 4500 605535469 CHVBK 20210128100847.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10517-015-2950-5 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2950-5 Effects of Melatonin on Stress-Induced Changes in the Liver of Rats with Different Resistance to Stress [Elektronische Daten] [V. Serikov, Yu. Lyashev] Effects of melatonin on changes in the liver structures were studied in stress-resistant and stress-sensitive rats exposed to chronic stress. It was found that the number of degenerative cells increased and intralobular sinusoidal capillary enlarged in the liver of animals of both groups. These parameters were significantly higher in stress-sensitive rats. Melatonin (1 mg/kg) reduced the severity of degenerative changes and stimulated the development of reparative processes in the liver tissue. The effects of the hormone was more pronounced in rats sensitive to stress and was noted after melatonin administration in a dose of 0.2 mg/kg. Springer Science+Business Media New York, 2015 liver nationallicence chronic stress nationallicence melatonin nationallicence Serikov V. Department of Pathophysiology, Kursk State Medical University, Kursk, Russia aut Lyashev Yu Department of Pathophysiology, Kursk State Medical University, Kursk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 314-317 0007-4888 159:3<314 2015 159 10517 https://doi.org/10.1007/s10517-015-2950-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2950-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Serikov V. Department of Pathophysiology, Kursk State Medical University, Kursk, Russia aut NATIONALLICENCE 700 1- Lyashev Yu Department of Pathophysiology, Kursk State Medical University, Kursk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/3(2015-07-01), 314-317 0007-4888 159:3<314 2015 159 10517