Molecular Factors of Cytokine-Dependent Activation of T Cells in Pulmonary Tuberculosis
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2971-0 |2 doi |
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| 245 | 0 | 0 | |a Molecular Factors of Cytokine-Dependent Activation of T Cells in Pulmonary Tuberculosis |h [Elektronische Daten] |c [I. Esimova, O. Urazova, M. Ignatova, V. Novitskii, Yu. Kolobovnikova] |
| 520 | 3 | |a The parameters characterizing antituberculous immune response at the stage of cytokinedependent activation of T cells were analyzed in 90 patients with pulmonary tuberculosis before etiotropic therapy. Immunophenotyping of T cells for IL-12Rβ2, WSX-1, and gp130 surface markers and T-bet intracellular transcription factor was carried out after specific IL-12/IL-27 induction of cells in vitro. An increase in the counts of CD3+T-bet+, CD3+IL-12Rβ2 +, and CD3+WSX-1+gp130+ cells and the level of T cells with high expression of WSX-1 inhibitory molecule (CD3+WSX-1hi+gp130− and CD3+WSX-1hi+gp130+) was detected. The type of disorders in the inductive stage of antituberculous immune response did not depend on the clinical form of disease. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a T cells |2 nationallicence | |
| 690 | 7 | |a activation |2 nationallicence | |
| 690 | 7 | |a interleukins |2 nationallicence | |
| 690 | 7 | |a molecular mechanisms |2 nationallicence | |
| 690 | 7 | |a pulmonary tuberculosis |2 nationallicence | |
| 700 | 1 | |a Esimova |D I. |u Siberian State Medical University, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Urazova |D O. |u Siberian State Medical University, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Ignatova |D M. |u Siberian State Medical University, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Novitskii |D V. |u Siberian State Medical University, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Kolobovnikova |D Yu |u Siberian State Medical University, Tomsk, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/3(2015-07-01), 390-392 |x 0007-4888 |q 159:3<390 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2971-0 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2971-0 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Esimova |D I. |u Siberian State Medical University, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Urazova |D O. |u Siberian State Medical University, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ignatova |D M. |u Siberian State Medical University, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Novitskii |D V. |u Siberian State Medical University, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kolobovnikova |D Yu |u Siberian State Medical University, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/3(2015-07-01), 390-392 |x 0007-4888 |q 159:3<390 |1 2015 |2 159 |o 10517 | ||